Search results

• 2011

  The production of 'aerodynamically equivalent' drug and excipient inhalable powders using a novel fractionation technique

  Taki, M., Marriott, C., Zeng, X.-M. & Martin, G. P., Feb 2011, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 77, 2, p. 283 - 296 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Fractionation 100%
  • Fluticasone Propionate 66%
  • Salmeterol Xinafoate 66%
  • Crystallization 33%
  • Inhalation 33%
  7 Citations (Scopus)

• The 'stage-by-stage' deposition of drugs from commercial single-active and combination dry powder inhaler formulations

  Taki, M., Ahmed, S., Marriott, C., Zeng, X.-M. & Martin, G. P., 17 Jul 2011, In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 43, 4, p. 225 - 235 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluticasone Propionate 100%
  • Salmeterol Xinafoate 100%
  • Inhalation 40%
  • Fluticasone Propionate Plus Salmeterol Xinafoate 40%
  14 Citations (Scopus)
• 2010

  Aerodynamic deposition of combination dry powder inhaler formulations in vitro: A comparison of three impactors

  Taki, M., Marriott, C., Zeng, X.-M. & Martin, G. P., 30 Mar 2010, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 388, 1-2, p. 40 - 51 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cascade Impactor 100%
  • Stages 75%
  • Multistage 50%
  • Flow Rate 50%
  • Fluticasone Propionate Plus Salmeterol Xinafoate 40%
  66 Citations (Scopus)

• Modelling the effects of microgravity on the permeability of air interface respiratory epithelial cell layers

  dos Santos, M. A., Bosquillon, C., Russomano, T., Sundaresan, A., Falcao, F., Marriott, C. & Forbes, B., 15 Sept 2010, In: ADVANCES IN SPACE RESEARCH. 46, 6, p. 712 - 718 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Air Interface 100%
  • Diffusion 42%
  • Microgravity Condition 25%
  3 Citations (Scopus)
• 2007

  Influence of realistic inspiratory flow profiles on fine particle fractions of dry powder aerosol formulations

  Martin, G. P., Marriott, C. & Zeng, X. M., Feb 2007, In: Pharmaceutical Research. 24, 2, p. 361 - 369 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Inhalation 100%
  • Maltose 66%
  • Terbutaline 33%
  17 Citations (Scopus)
• 2006

  Characterisation of a carrier-free dry powder aerosol formulation using inertial impaction and laser diffraction

  Martin, G. P., MacRitchie, H. B., Marriott, C. & Zeng, X.-M., Sept 2006, In: Pharmaceutical Research. 23, 9, p. 2210 - 2219 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Inertial Impaction 100%
  • Aerosol 100%
  • Flow Rate 50%
  • Particle-Size Distribution 50%
  • Nonoxynol-9 50%
  17 Citations (Scopus)

• Correlation between inertial impaction and laser diffraction sizing data for aerosolized carrier-based dry power formulations

  Zeng, X.-M., MacRitchie, H. B., Marriott, C. & Martin, G. P., Sept 2006, In: Pharmaceutical Research. 23, 9, p. 2200 - 2209 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Salbutamol Sulfate 100%
  • Maltose 100%
  16 Citations (Scopus)

• Development of a laser diffraction method for the determination of the particle size of aerosolized powder formulations

  Marriott, C., MacRitchie, H. B., Zeng, X.-M. & Martin, G. P., 1 Dec 2006, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 326, 1-2, p. 39 - 49 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Particle-Size Distribution 100%
  • Powder Formulation 100%
  • Aerosol 100%
  • Dextrose 66%
  • Inhalation 33%
  25 Citations (Scopus)

• Validation of a reverse-phase high performance liquid chromatographic method for concurrent assay of a weak base (salmeterol xinafoate) and a pharmacologically active steroid (fluticasone propionate)

  Murnane, D., Martin, G. P. & Marriott, C., 18 Mar 2006, In: Journal of Pharmaceutical and Biomedical Analysis. 40, 5, p. 1149 - 1154 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Liquid Chromatography 100%
  • Salmeterol Xinafoate 100%
  • Fluticasone Propionate 100%
  • Concentration 14%
  • Dose 14%
  49 Citations (Scopus)
• 2005

  The effect of unsaturated fatty acids in benzyl alcohol on the percutaneous permeation of three model penetrants

  Nanayakkara, G. R., Bartlett, A., Forbes, B., Marriott, C., Whitfield, P. J. & Brown, M. B., 14 Sept 2005, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 301, 1-2, p. 129 - 139 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Solution and Solubility 100%
  • Unsaturated Fatty Acid 100%
  • Fatty Acid 80%
  • Facilitated Diffusion 20%
  • Lipophilicity 20%
  46 Citations (Scopus)
• 2004

  A comparison of topical formulations for the prevention of human schistosomiasis

  Cooper, E., Iqbal, A., Bartlett, A., Marriott, C., Whitfield, P. J. & Brown, M. B., Aug 2004, In: Journal of Pharmacy and Pharmacology. 56, 8, p. 957 - 962 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Diethyltoluamide 100%
  • Cercaria 80%
  6 Citations (Scopus)
• 2003

  Characterisation and deposition studies of engineered lactose crystals with potential for use as a carrier for aerosolised salbutamol sulfate from dry powder inhalers

  Larhrib, H., Martin, G. P., Prime, D. & Marriott, C., Jul 2003, In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 19, 4, p. 211 - 221 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Salbutamol Sulfate 100%
  • Crystals 100%
  • Particles 50%
  • Crystallization 37%
  • X-Ray 25%
  75 Citations (Scopus)

• Delayed tail loss during the invasion of human skin by schistosome cercariae

  Whitfield, P. J., Bartlett, A., Khammo, N., Brain, A. P. R., Brown, M. B., Marriott, C. & Clothier, R., 1 Feb 2003, In: Parasitology. 126, 2, p. 135 - 140 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Schistosoma 100%
  • Schistosomiasis 50%
  • Scanning Electron Microscopy 50%
  15 Citations (Scopus)

• Invasion by schistosome cercariae: studies with human skin explants

  Whitfield, P. J., Bartlett, A., Brown, M. B. & Marriott, C., 1 Aug 2003, In: TRENDS IN PARASITOLOGY. 19, 8, p. 339 - 340 2 p.

  Research output: Contribution to journal › Letter › peer-review

  18 Citations (Scopus)

• Penetration of human skin by the cercariae of Schistosoma mansoni: an investigation of the effect of multiple cercarial applications

  Ingram, R. J., Bartlett, A., Brown, M. B., Marriott, C. & Whitfield, P. J., Mar 2003, In: Journal of Helminthology. 77, 1, p. 27 - 31 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Group 100%
  • Application 100%
  • Schistosoma Mansoni 100%
  • Cercaria 100%
  • L-Arginine 50%
  7 Citations (Scopus)

• The influence of carrier and drug morphology on drug delivery from dry powder formulations

  Larhrib, H., Martin, G. P., Marriott, C. & Prime, D., 12 May 2003, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 257, 1-2, p. 283 - 296 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Delivery 100%
  • Powder Formulation 100%
  • Salbutamol Sulfate 100%
  • Ethanol 66%
  • Differential Scanning Calorimetry 33%
  153 Citations (Scopus)

• The in vitro assessment of aerosolised drug deposition using novel oropharyngeal models

  Masoud, O., Martin, G. P., Marriott, C. & Nichols, S., 2003, Drug Delivery to the Lungs XIII. International Society for Aerosols in Medicine, p. 27 - 30 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2002

  Dimethicone barrier cream prevents infection of human skin by Schistosome cercariae: Evidence from Franz cell studies

  Ingram, R. J., Bartlett, A., Brown, M. B., Marriott, C. & Whitfield, P. J., 2002, In: Journal of Parasitology. 88, 2, p. 399 - 402 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Infection 100%
  • Cells 100%
  • Dimeticone 100%
  • Cercaria 100%
  • Schistosomiasis 50%
  8 Citations (Scopus)

• Poly (lactic acid) microspheres as a means of drug delivery to the lung: the effect of process variables on particle size

  Al-Najar, M. A., Martin, G. P. & Marriott, C., 2002, In: Drug Delivery to the Lungs- Aerosol Society. 13, p. 83 - 86 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2001

  An in vivo evaluation of salbutamol delivery from binary and ternary dry powder inhaler formulations

  Tee, S., Martin, G., Leeds, A., Kicman, A., Cowan, D. & Marriott, C., 2001, In: JOURNAL OF AEROSOL MEDICINE. 14, 3, p. 415 1 p.

  Research output: Contribution to journal › Article › peer-review

• Effects of molecular weight of polyvinylpyrrolidone on the glass transition and crystallization of co-lyophilized sucrose

  Zeng, X. M., Martin, G. P. & Marriott, C., 7 May 2001, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 218, 1-2, p. 63 - 73 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Sucrose 100%
  • Differential Scanning Calorimetry 6%
  • Freeze-Drying 6%
  • Analysis of Variance 6%
  50 Citations (Scopus)

• In vitro/in vivo evaluation of the performance of two lactose carrier-based dry powder aerosol formulations for the delivery of salbutamol to the lung

  Tee, S. K., Martin, G. P., Leeds, A., Walker, C., Kicman, A., Cowan, D., Fallon, J. & Marriott, C., 2001, Drug Delivery to the Lungs XI. Aerosol Society, p. 176 - 179 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• In vivo determination of salbutamol sulphate delivered from a dry powder inhaler formulation in human plasma and urine by solid phase extraction/gas chromatographymass spectrometry

  Tee, S. K., Marriott, C., Leeds, A. R., Walker, C., Kicman, A., Cowan, D. A. & Martin, G. P., 2001, British Pharmaceutical Conference: science proceedings. Pharmaceutical Press, p. 15 - ?

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper

• Lactose as a carrier in dry powder formulations: The influence of surface characteristics on drug delivery

  Zeng, X. M., Martin, G. P., Marriott, C. & Pritchard, J., 2001, In: Journal of Pharmaceutical Sciences. 90, 9, p. 1424 - 1434 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Delivery 100%
  • Powder Formulation 100%
  • Ethanol 10%
  • Inhalation 10%
  • Salbutamol Sulfate 10%
  137 Citations (Scopus)

• Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium

  Ferrari, S., Kitson, C., Farley, R., Steel, R., Marriott, C., Parkins, D. A., Scarpa, M., Wainwright, B., Evans, M. J., Colledge, W. H., Geddes, D. M. & Alton, E. W. F. W., 2001, In: Gene Therapy. 8, 18, p. 1380 - 1386 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Therapy 100%
  • Cationic Lipid 50%
  • Bioenergy 50%
  • Gene Transfer Agent 50%
  • Gene 50%
  105 Citations (Scopus)

• Oropharyngeal models as ports of entry for the in vitro assessment of aerosolised drug deposition

  Masoud, O., Marriott, C., Martin, G. & Nicols, S., 2001, In: JOURNAL OF AEROSOL MEDICINE. 14, 3, p. 416 1 p.

  Research output: Contribution to journal › Article › peer-review

• Particulate interactions in dry powder formulations for inhalation

  Zeng, X. M., Martin, G. P. & Marriott, C., 2001, London ; New York: Taylor & Francis.

  Research output: Book/Report › Book

• Poly(lactic-co-glycolic) microspheres as a means of drug delivery to the lung: the effect of process variables on particle size

  Al-Najar, M. A., Martin, G. P. & Marriott, C., 2001, Drug delivery to the lungs XII. Bristol: Aerosol Society, p. 131 - 134 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• The effects of micronisation on the particle size and solid state structure of lactose

  Larhrib, H., Mpanga-Sempa, O., Marriott, C. & Martin, G., 2001, British Pharmaceutical Conference: science proceedings. Pharmaceutical Press, p. 253 - ?

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper

• The influence of a tertiary component on the in vivo disposition of salbutamol isomers aerosolised from a dry powder inhaler formulation

  Tee, S. K., Martin, G. P., Leeds, A. R., Walker, C., Kicman, A., Cowan, D. A. & Marriott, C., 2001, In: Thorax. 56, p. 61 - 62 2 p.

  Research output: Contribution to journal › Meeting abstract

• The In Vitro assessment of aerosolised drug deposition using novel oropharyngeal models

  Masoud, O., Martin, G. P., Marriott, C. & Nichols, S., 2001, Drug delivery to the lungs XII. Bristol: Aerosol Society, p. 31 - 34 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• The use of lactose recrystallised from carbopol gels as a carrier for aerosolised salbutamol sulphate

  Zeng, X. M., Martin, G. P., Marriott, C. & Pritchard, J., 2001, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 51, 1, p. 55 - 62 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Salbutamol Sulfate 100%
  • Drug Delivery 7%
  • Sieving 7%
  71 Citations (Scopus)

• The use of particle engineering to design carriers and drug for respiratory drug delivery

  Lahrib, H., Martin, G. P., Marriott, C. & Prime, D., 2001, Drug Delivery to the Lungs XI. Aerosol Society, p. 18 - 21 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2000

  A human oral-throat cast integrated with a twin-stage impinger for evaluation of dry powder inhalers

  Srichana, T., Martin, G. P. & Marriott, C., Jul 2000, In: Journal of Pharmacy and Pharmacology. 52, 7, p. 771 - 778 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Salbutamol Sulfate 100%
  16 Citations (Scopus)

• Anti-mucus polyclonal antibody production, purification and linkage to the surface of albumin microspheres

  MacAdam, A. B., Shafi, Z. B., Marriott, C., Martin, G. P. & James, S. L., 15 Feb 2000, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 195, 1-2, p. 147 - 158 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mucus 100%
  • Drug Delivery System 40%
  • Cross-Reactivity 37%
  • Pig 20%
  • Leporidae 20%
  12 Citations (Scopus)

• A study of drug-carrier interactions in dry powder inhaler formulations using the Andersen cascade impactor, X-ray microanalysis and time of flight aerosol beam spectrometry (TOFABS)

  Srichana, T., Brain, P., Marriott, C. & Martin, G. P., Feb 2000, In: Chemical and Pharmaceutical Bulletin. 48, 2, p. 167 - 174 8 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Ray 100%
  • Salbutamol Sulfate 50%
  • Scanning Electron Microscopy 33%
  • Lactose Permease 16%
  12 Citations (Scopus)

• Crystallization of lactose from Carbopol gels

  Zeng, X. M., Martin, G. P., Marriott, C. & Pritchard, J., 2000, In: Pharmaceutical Research. 17, 7, p. 879 - 886 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Crystallization 100%
  • Gel 100%
  • Particle Size 25%
  • Ethanol 14%
  • Microscopy 14%
  32 Citations (Scopus)

• Systematic investigations of the influence of molecular structure on the transport of peptides across cultured alveolar cell monolayers

  Dodoo, A. N. O., Bansal, S., Barlow, D. J., Bennet, F. C., Hider, R. C., Lansley, A. B., Lawrence, M. J. & Marriott, C., 2000, In: Pharmaceutical Research. 17, 1, p. 7 - 14 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Monolayers 100%
  • Chemical Structure 100%
  • Apparent Permeability 33%
  • Permeability 28%
  • Amino Acids 14%
  19 Citations (Scopus)

• The effects of carrier size and morphology on the dispersion of salbutamol sulphate after aerosolization at different flow rates

  Zeng, X. M., Martin, G. P., Marriott, C. & Pritchard, J., 2000, In: Journal of Pharmacy and Pharmacology. 52, 10, p. 1211 - 1221 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Salbutamol Sulfate 100%
  • Inhalation 14%
  62 Citations (Scopus)

• The infection of human skin by schistosome cercariae: studies using Franz cells

  Bartlett, A., Brown, M., Marriott, C. & Whitfield, P. J., 2000, In: Parasitology. 121, 1, p. 49 - 54 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Schistosoma 100%
  • Diffusion 16%
  28 Citations (Scopus)

• The influence of carrier morphology on drug delivery by dry powder inhalers

  Zeng, X. M., Martin, G. P., Marriott, C. & Pritchard, J., 25 Apr 2000, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 200, 1, p. 93 - 106 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Delivery 100%
  • Salbutamol Sulfate 100%
  • Inhalation 14%
  • Powder Formulation 14%
  227 Citations (Scopus)

• The influence of crystallization conditions on the morphology of lactose intended for use as a carrier for dry powder aerosols

  Zeng, X. M., Martin, G. P., Marriott, C. & Pritchard, J., Jun 2000, In: Journal of Pharmacy and Pharmacology. 52, 6, p. 633 - 643 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Aerosol 100%
  • Crystallization 100%
  • Glycerol 66%
  • Ethanol 66%
  • Acetone 66%
  57 Citations (Scopus)

• The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate

  Tee, S. K., Marriott, C., Zeng, X. M. & Martin, G. P., 4 Nov 2000, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 208, 1-2, p. 111 - 123 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Salbutamol Sulfate 100%
  119 Citations (Scopus)

• Use of alveolar cell monolayers of varying electrical resistance to measure pulmonary peptide transport

  Dodoo, A. N. O., Bansal, S. S., Barlow, D. J., Bennet, F., Hider, R. C., Lansley, A. B., Lawrence, M. J. & Marriott, C., Feb 2000, In: Journal of Pharmaceutical Sciences. 89, 2, p. 223 - 231 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Electrical Resistance 100%
  • Monolayers 100%
  • Membrane 11%
  • Permeability 11%
  • Molecule 11%
  15 Citations (Scopus)
• 1999

  The influence of hydrocolloid patch composition on the bioavailability of triamcinolone acetonide in humans

  Martin, G. P., Ladenheim, D., Marriott, C., Hollingsbee, D. A. & Brown, M. B., 1999, In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 26, 1, p. 35 - 43 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Human 100%
  • Bioavailability 100%
  • Triamcinolone Acetonide 100%
  • Adrenal Cortex Hormone 60%
  • Drug 50%