Search results

• 2011

  Research potential of archival fixed tissue: DNA preservation and immuno-reactivity

  Troakes, C., Spandoni, V., Hortobagyi, T., Bodi, I., King, A. & Al-Sarraj, S., 2011, In: Neuropathology and Applied Neurobiology. 37, p. 31 - 32 2 p.

  Research output: Contribution to journal › Meeting abstract

• Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

  Engmann, O., Hortobagyi, T., Pidsley, R., Troakes, C., Bernstein, H.-G., Kreutz, M. R., Mill, J., Nikolic, M. & Giese, K. P., Aug 2011, In: Brain. 134, 8, p. 2408 - 2421 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognition 100%
  • Brain 28%
  • Cognitive Disorders 28%
  • Cyclin Dependent Kinase 5 28%
  92 Citations (Scopus)

• Ubiquitinated, p62 immunopositive cerebellar cortical inclusions in TDP-43 proteinopathies

  King, A., Maekawa, S., Bodi, I., Troakes, C. & Al-Sarraj, S., 2011, In: Neuropathology and Applied Neurobiology. 37, p. 36 - 36 1 p.

  Research output: Contribution to journal › Meeting abstract

  3 Citations (Scopus)

• Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43

  King, A., Maekawa, S., Bodi, I., Troakes, C. & Al-Sarraj, S., Jun 2011, In: Neuropathology. 31, 3, p. 239 - 249 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Transactive Response Dna Binding Protein-43 100%
  • TDP 43 Proteinopathy 100%
  • Frontotemporal Dementia 100%
  • Frontotemporal Lobar Degeneration 71%
  • Cerebellum 60%
  59 Citations (Scopus)
• 2010

  Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease

  King, A., Sweeney, F., Bodi, I., Troakes, C., Maekawa, S. & Al-sarraj, S., Aug 2010, In: Neuropathology. 30, 4, p. 408-419 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia 100%
  • Neocortex 100%
  • Frontotemporal Dementia 100%
  • Limbic System 100%
  • Neurodegenerative Disorder 16%
  98 Citations (Scopus)

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP43 inclusions

  Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L.-S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., Arnold, S. E., Mann, D. M. A., Pickering-Brown, S. M., Seelaar, H., Heutink, P., van Swieten, J. C., Murrell, J. R., Ghetti, B., Spina, S. & Grafman, J. & 80 others, Hodges, J., Spillantini, M. G., Gilman, S., Lieberman, A. P., Kaye, J. A., Woltjer, R. L., Bigio, E. H., Mesulam, M., al-Sarraj, S., Troakes, C., Rosenberg, R. N., White, C. L., Ferrer, I., Llado, A., Neumann, M., Kretzschmar, H. A., Hulette, C. M., Welsh-Bohmer, K. A., Miller, B. L., Alzualde, A., Lopez de Munain, A., McKee, A. C., Gearing, M., Levey, A. I., Lah, J. J., Hardy, J., Rohrer, J. D., Lashley, T., Mackenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Dekosky, S. T., van der Zee, J., Kumar-Singh, S., Van Broeckhoven, C., Mayeux, R., Vonsattel, J. P. G., Troncoso, J. C., Kril, J. J., Kwok, J. B. J., Halliday, G. M., Bird, T. D., Ince, P. G., Shaw, P. J., Cairns, N. J., Morris, J. C., McLean, C. A., DeCarli, C., Ellis, W. G., Freeman, S. H., Frosch, M. P., Growdon, J. H., Perl, D. P., Sano, M., Bennett, D. A., Schneider, J. A., Beach, T. G., Reiman, E. M., Woodruff, B. K., Cummings, J., Vinters, H. V., Miller, C. A., Chui, H. C., Alafuzoff, I., Hartikainen, P., Seilhean, D., Galasko, D., Masliah, E., Cotman, C. W., Tunon, M. T., Martinez, M. C. C., Munoz, D. G., Carroll, S. L., Marson, D., Riederer, P. F., Bogdanovic, N., Schellenberg, G. D., Hakonarson, H., Trojanowski, J. Q. & Lee, V.M.-Y., Mar 2010, In: Nature Genetics. 42, 3, p. 234 - U34 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Frontotemporal Lobar Degeneration 100%
  • Frontotemporal Dementia 100%
  • Single Nucleotide Polymorphism 25%
  • Association 16%
  • Genome Wide Association Study 8%
  454 Citations (Scopus)

• Cytoplasmic TDP-43 accumulation is related to nuclear transport dysfunction in frontotemporal lobar degeneration and motor neuron disease

  Hortobagyi, T., Nishimura, A. L., Troakes, C., Kathe, C., Fratta, P., Howell, M., Gallo, J.-M., Shaw, C. E. & Rogelj, B., 2010, In: Brain Pathology. 20, p. 24 - 24 1 p.

  Research output: Contribution to journal › Meeting abstract

• Effects of cis-regulatory variation differ across regions of the adult human brain

  Buonocore, F., Hill, M. J., Campbell, C. D., Oladimeji, P. B., Jeffries, A. R., Troakes, C., Hortobagyi, T., Williams, B. P., Cooper, J. D. & Bray, N. J., 15 Nov 2010, In: Human Molecular Genetics. 19, 22, p. 4490 - 4496 7 p., N/A.

  Research output: Contribution to journal › Article › peer-review

  • RNA 100%
  • Candidate Gene 100%
  • NOS1 100%
  • RGS4 100%
  • Gene 100%
  36 Citations (Scopus)

• Familial TDP proteinopathy with ALS presentation: characteristic clinical and pathological features

  Troakes, C., Maekawa, S., Wijesekera, L., Rogelj, B., Smith, B., Vance, C., Hortobagyi, T., Arzberger, T., Kretzschmar, H., Leigh, N., Al-Chalabi, A., Shaw, C., King, A. & Al-Sarraj, S., 2010, In: Brain Pathology. 20, p. 33 - 33 1 p.

  Research output: Contribution to journal › Meeting abstract

• Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

  Nishimura, A. L., Zupunski, V., Troakes, C., Kathe, C., Fratta, P., Howell, M., Gallo, J.-M., Hortobagyi, T., Shaw, C. E. & Rogelj, B., 26 May 2010, In: Brain. 133, 6, p. 1763 - 1771 9 p., N/A.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transactivation 100%
  • Transactive Response Dna Binding Protein-43 100%
  • Nuclear Transport 40%
  • Protein 38%
  • Brain 20%
  163 Citations (Scopus)