TY - JOUR
T1 - Abnormal microstructural development of the cerebral cortex in neonates with congenital heart disease is associated with impaired cerebral oxygen delivery
AU - Kelly, Christopher John
AU - Christiaens, Daan Julia Paul
AU - Batalle, Dafnis
AU - Makropulos, Antonis
AU - Cordero Grande, Lucilio
AU - Steinweg, Johannes Klaus
AU - O'Muircheartaigh, Jonathan
AU - Khan, Hammad
AU - Lee, Geraint
AU - Victor, Suresh
AU - Daniel, Alexander
AU - Zhang, Hui
AU - Simpson, John
AU - Hajnal, Joseph Vilmos
AU - Edwards, Anthony David
AU - Rutherford, Mary Ann
AU - Counsell, Serena Jane
PY - 2019/3/15
Y1 - 2019/3/15
N2 - Background: Abnormal macrostructural development of the cerebral cortex has been associated with hypoxia in infants with congenital heart disease (CHD). Animal studies have suggested that hypoxia results in cortical dysmaturation at the cellular level. New magnetic resonance imaging (MRI) techniques offer the potential to investigate the relationship between cerebral oxygen delivery and microstructural development of the cortex in newborn infants with CHD. Methods: We measured macrostructural and microstructural properties of the cortex in 48 newborn infants with complex CHD and 48 age-matched healthy controls. Cortical volume and gyrification index were calculated from high resolution structural MRI. Neurite density and orientation dispersion indices were modelled using high angular resolution diffusion MRI. Cerebral oxygen delivery was estimated in infants with CHD using phase contrast MRI and pre-ductal pulse oximetry. We used tract-based spatial statistics to examine voxel-wise group differences in cortical microstructure. Results: Microstructural development of the cortex was abnormal in 48 infants with CHD, with regions of increased fractional anisotropy (FA) and reduced orientation dispersion index (ODI) compared to 48 healthy controls, correcting for gestational age at birth and scan (FWE-corrected for multiple comparisons at P
AB - Background: Abnormal macrostructural development of the cerebral cortex has been associated with hypoxia in infants with congenital heart disease (CHD). Animal studies have suggested that hypoxia results in cortical dysmaturation at the cellular level. New magnetic resonance imaging (MRI) techniques offer the potential to investigate the relationship between cerebral oxygen delivery and microstructural development of the cortex in newborn infants with CHD. Methods: We measured macrostructural and microstructural properties of the cortex in 48 newborn infants with complex CHD and 48 age-matched healthy controls. Cortical volume and gyrification index were calculated from high resolution structural MRI. Neurite density and orientation dispersion indices were modelled using high angular resolution diffusion MRI. Cerebral oxygen delivery was estimated in infants with CHD using phase contrast MRI and pre-ductal pulse oximetry. We used tract-based spatial statistics to examine voxel-wise group differences in cortical microstructure. Results: Microstructural development of the cortex was abnormal in 48 infants with CHD, with regions of increased fractional anisotropy (FA) and reduced orientation dispersion index (ODI) compared to 48 healthy controls, correcting for gestational age at birth and scan (FWE-corrected for multiple comparisons at P
KW - brain imaging
KW - cerebral blood flow
KW - congenital heart disease
KW - development
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85064495865&partnerID=8YFLogxK
U2 - 10.1101/332247
DO - 10.1101/332247
M3 - Article
SN - 2047-9980
VL - 8
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 5
M1 - e009893
ER -