Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

CORGI Consortium

doi:10.1038/ng.2007.41

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

CORGI Consortium

Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK.

Research output: Contribution to journal › Article › peer-review

260 Citations (Scopus)

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).

Original language	English
Pages (from-to)	26-8
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	1
DOIs	https://doi.org/10.1038/ng.2007.41
Publication status	Published - Jan 2008

Keywords

Adenoma/genetics
Cell Line, Tumor
Cells, Cultured
Chromosomes, Human, Pair 15
Colorectal Neoplasms/genetics
Genetic Predisposition to Disease
Humans
Jews/genetics
Polymorphism, Single Nucleotide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.2007.41

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title = "Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk",

abstract = "We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).",

keywords = "Adenoma/genetics, Cell Line, Tumor, Cells, Cultured, Chromosomes, Human, Pair 15, Colorectal Neoplasms/genetics, Genetic Predisposition to Disease, Humans, Jews/genetics, Polymorphism, Single Nucleotide",

author = "{CORGI Consortium} and Emma Jaeger and Emily Webb and Kimberley Howarth and Luis Carvajal-Carmona and Andrew Rowan and Peter Broderick and Axel Walther and Sarah Spain and Alan Pittman and Zoe Kemp and Kate Sullivan and Karl Heinimann and Steven Lubbe and Enric Domingo and Ella Barclay and Lynn Martin and Maggie Gorman and Ian Chandler and Jayaram Vijayakrishnan and Wendy Wood and Elli Papaemmanuil and Steven Penegar and Mobshra Qureshi and Susan Farrington and Albert Tenesa and Jean-Baptiste Cazier and David Kerr and Richard Gray and Julian Peto and Malcolm Dunlop and Harry Campbell and Huw Thomas and Richard Houlston and Ian Tomlinson",

year = "2008",

month = jan,

doi = "10.1038/ng.2007.41",

language = "English",

volume = "40",

pages = "26--8",

journal = "Nature Genetics",

issn = "1061-4036",

number = "1",

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T1 - Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

AU - CORGI Consortium

AU - Jaeger, Emma

AU - Webb, Emily

AU - Howarth, Kimberley

AU - Carvajal-Carmona, Luis

AU - Rowan, Andrew

AU - Broderick, Peter

AU - Walther, Axel

AU - Spain, Sarah

AU - Pittman, Alan

AU - Kemp, Zoe

AU - Sullivan, Kate

AU - Heinimann, Karl

AU - Lubbe, Steven

AU - Domingo, Enric

AU - Barclay, Ella

AU - Martin, Lynn

AU - Gorman, Maggie

AU - Chandler, Ian

AU - Vijayakrishnan, Jayaram

AU - Wood, Wendy

AU - Papaemmanuil, Elli

AU - Penegar, Steven

AU - Qureshi, Mobshra

AU - Farrington, Susan

AU - Tenesa, Albert

AU - Cazier, Jean-Baptiste

AU - Kerr, David

AU - Gray, Richard

AU - Peto, Julian

AU - Dunlop, Malcolm

AU - Campbell, Harry

AU - Thomas, Huw

AU - Houlston, Richard

AU - Tomlinson, Ian

PY - 2008/1

Y1 - 2008/1

N2 - We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).

AB - We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).

KW - Adenoma/genetics

KW - Cell Line, Tumor

KW - Cells, Cultured

KW - Chromosomes, Human, Pair 15

KW - Colorectal Neoplasms/genetics

KW - Genetic Predisposition to Disease

KW - Humans

KW - Jews/genetics

KW - Polymorphism, Single Nucleotide

U2 - 10.1038/ng.2007.41

DO - 10.1038/ng.2007.41

M3 - Article

C2 - 18084292

SN - 1061-4036

VL - 40

SP - 26

EP - 28

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Abstract

Keywords

UN SDGs

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