Delayed tail  loss during the invasion of human skin by schistosome cercariae

P J Whitfield; A Bartlett; N Khammo; A P R Brain; M B Brown; C Marriott; R Clothier

doi:10.1017/S0031182002002676

Delayed tail loss during the invasion of human skin by schistosome cercariae

P J Whitfield, A Bartlett, N Khammo, A P R Brain, M B Brown, C Marriott, R Clothier

King's College London

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Schistosomiasis is initiated when cercarial larvae invade human skin. Contrary to long-held assumptions, most cercariae of Schistosoma mansoni do not shed their propulsive tails as they penetrate. Scanning electron microscopy studies and infection experiments with entire human skin and differentiated, stratum corneum-like, human keratinocyte cultures, have shown that most cercarial tails enter the skin along with their bodies. We propose that this behaviour is an adaptive trait linked with concomitant immunity.

Original language	English
Pages (from-to)	135 - 140
Number of pages	6
Journal	Parasitology
Volume	126
Issue number	2
DOIs	https://doi.org/10.1017/S0031182002002676
Publication status	Published - 1 Feb 2003

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abstract = "Schistosomiasis is initiated when cercarial larvae invade human skin. Contrary to long-held assumptions, most cercariae of Schistosoma mansoni do not shed their propulsive tails as they penetrate. Scanning electron microscopy studies and infection experiments with entire human skin and differentiated, stratum corneum-like, human keratinocyte cultures, have shown that most cercarial tails enter the skin along with their bodies. We propose that this behaviour is an adaptive trait linked with concomitant immunity.",

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AU - Brown, M B

AU - Marriott, C

AU - Clothier, R

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AB - Schistosomiasis is initiated when cercarial larvae invade human skin. Contrary to long-held assumptions, most cercariae of Schistosoma mansoni do not shed their propulsive tails as they penetrate. Scanning electron microscopy studies and infection experiments with entire human skin and differentiated, stratum corneum-like, human keratinocyte cultures, have shown that most cercarial tails enter the skin along with their bodies. We propose that this behaviour is an adaptive trait linked with concomitant immunity.

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Delayed tail loss during the invasion of human skin by schistosome cercariae

Abstract

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