Research output per year
Research output per year
Personal profile
Research interests
I am a synthetic chemical biologist whose research spans fundamental questions in engineering biology about the hallmarks of life, genetic information storage and the evolution of biochemical function, and how we can engineer artifical biology, or 'xenobiology', towards applications in molecular medicine. My lab explores the selection and design of artificial analogues of DNA and RNA known as Xeno-Nucleic Acids (XNAs), synthetic polymers with properties beyond nature's genetic material.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
Dive into the research topics where Alexander Taylor is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA
Freund, N., Taylor, A. I., Arangundy-Franklin, S., Subramanian, N., Peak-Chew, S. Y., Whitaker, A. M., Freudenthal, B. D., Abramov, M., Herdewijn, P. & Holliger, P., Jan 2023, In: Nature Chemistry. 15, 1, p. 91-100 10 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Citations (Scopus) -
Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
Taylor, A., Schofield, P., Rihon, J., Pena Martinez, C., Zinn, S., Mattelaer, C.-A., Jackson, J., Dhaliwal, G., Schepers, G., Herdewijn, P., Lescrinier, E., Christ, D. & Holliger, P., 25 Aug 2023, In: Nucleic Acids Research. 51, 15, p. 7736-7748Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing
Taylor, A. I., Wan, C. J. K., Donde, M. J., Peak-Chew, S. Y. & Holliger, P., Nov 2022, In: Nature Chemistry. 14, 11, p. 1295-1305 11 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Citations (Scopus) -
Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues
Hervey, J. R. D., Freund, N., Houlihan, G., Dhaliwal, G., Holliger, P. & Taylor, A. I., 30 Aug 2022, In: RSC Chemical Biology. 3, 10, p. 1209-1215 7 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
On gene silencing by the X10-23 DNAzyme
Taylor, A. I. & Holliger, P., Aug 2022, In: Nature Chemistry. 14, 8, p. 855-858 4 p.Research output: Contribution to journal › Letter › peer-review
15 Citations (Scopus)
Projects
- 1 Active
-
Development of a new generation of biostable nucleic acid antibodies (aptamers), catalysts and nanostructures for precision biomedicine using synthetic genetic systems
Taylor, A. (Primary Investigator)
2/02/2024 → 28/02/2026
Project: Research