Research output per year
Research output per year
Personal profile
Research interests
Bacterial toxins that interfere with cellular signalling, in particular the Pasteurella multocida toxin; cellular microbiology; bacteria and cancer; G-protein regulation.
Research interests (short)
Bacterial toxins that interfere with cellular signalling; cellular microbiology; bacteria and cancer.
Biographical details
Alistair Lax’s first degree was in Biochemistry at the University of Glasgow. He obtained his PhD on Dictyostelium discoideum development at ICRF (now Cancer Research UK) in London in 1979. After a year as a supply teacher in Inner London, he was appointed to a staff position at the Institute for Animal Health in Berkshire to work on the transmissible spongiform encephalopathy, scrapie. He later moved into bacterial pathogenesis, working first on Salmonella virulence, then with Pasteurella multocida. Analysis of the mitogenic P. multocida toxin led him into the analysis of cellular signalling pathways, in particular those associated with G-protein signal pathways. This work led to his interest in the role of bacterial toxins in cancer.
In 1996 he joined King’s as a Senior Lecturer, and from 2002 has been Professor of Cellular Microbiology.
He was Director of Graduate Studies at the Dental Institute from 2002 until 2015.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Promoter orientation of the immunomodulatory Bacteroides fragilis capsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD)
Blandford, L. E., Johnston, E. L., Sanderson, J. D., Wade, W. G. & Lax, A. J., 3 Sept 2019, In: Gut Microbes. 10, 5, p. 569-577 9 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer
Lax, A., 2012, In: Current Topics in Microbiology and Immunology. 361, p. 131-144 14 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
How bacteria could cause cancer: one step at a time
Lax, A. J. & Thomas, W., 1 Jun 2002, In: Trends in Microbiology. 10, 6, p. 293 - 299 7 p.Research output: Contribution to journal › Literature review › peer-review
199 Citations (Scopus)