Research output per year
Research output per year
Personal profile
Research interests
Overview
Research is focused on the development and biopharmaceutical application of respiratory and intestinal epithelial cell culture models. Drug permeability, metabolism and gene delivery are studied:
- enhancement of drug transport
- presystemic drug metabolism
- epithelial pathology / toxicity
Inhaled Drug Delivery
“Inhalation biopharmaceutics” encompasses anything that may affect the rate or extent of drug absorption from the lung. Research projects in this emerging field include:
- Dissolution in lung fluid
- Mucociliary and macrophage interactions
- Drug metabolism
- Epithelial permeability
- Toxicity of delivery vehicles (excipients, nanoparticles)
All these events occur at (or in) the respiratory epithelium.
Oral Drug Delivery
Current projects investigate interactions between intestinal fluid, the intestinal epithelium, orally administered drugs and formulation excipients.
Clinical Pharmaceutics
Projects with innovation aimed at improving practice in the manufacturing of pharmaceutical products.
Research interests (short)
Inhaled medicines; pulmonary biopharmaceutics; drug targeting to the lung.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery
Wingrove, J., O'Daly, O., De Lara Rubio, A., Hill, S., Swedroska, M., Forbes, B., Amiel, S. & Zelaya, F., 15 Dec 2022, In: Human Brain Mapping. 43, 18, p. 5432-5451 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)193 Downloads (Pure) -
Improving drug delivery for alzheimer’s disease through nose-to-brain delivery using nanoemulsions, nanostructured lipid carriers (NLC) and in situ hydrogels
Cunha, S., Forbes, B., Lobo, J. M. S. & Silva, A. C., 2021, In: International Journal of Nanomedicine. 16, p. 4373-4390 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access67 Citations (Scopus) -
Intranasal insulin administration decreases cerebral blood flow in cortico-limbic regions: A neuropharmacological imaging study in normal and overweight males
Wingrove, J. O., O'Daly, O., Forbes, B., Swedrowska, M., Amiel, S. A. & Zelaya, F. O., Jan 2021, In: Diabetes, Obesity and Metabolism. 23, 1, p. 175-185 11 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: Formulation variables and instrumental parameters
Cunha, S., Costa, C. P., Loureiro, J. A., Alves, J., Peixoto, A. F., Forbes, B., Lobo, J. M. S. & Silva, A. C., Jul 2020, In: Pharmaceutics. 12, 7, p. 1-27 27 p., 599.Research output: Contribution to journal › Article › peer-review
Open Access81 Citations (Scopus) -
Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging
Wingrove, J. O., Swedrowska, M., Scherliss, R., Parry, M., Ramjeeawon, M., Taylor, D. M., Gauthier, G., Brown, L., Amiel, S. A., Zelaya, F. O. & Forbes, B. J., 28 May 2019, In: JOURNAL OF CONTROLLED RELEASE. 302, p. 140-147 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)526 Downloads (Pure)