Dr Prischi is a Senior Lecturer at King's College London. He graduated with a BSc in Biological Sciences (summa cum laude) and an MSc in Molecular Biology (summa cum laude) from the University of Siena (Italy). He carried out a PhD in Biochemistry under the supervision of Prof Annalisa Pastore and Prof Neri Niccolai at the MRC National Institute for Medical Research. His thesis focused on the structural characterisation of frataxin and its interaction with the central components of iron–sulphur cluster. He then spent 5 years of productive postdoctoral research in Dr Ali Maruf's group at Imperial College London, studying the Unfolded Protein Response initiation and the phosphoregulation of Ire1 RNase splicing activity. In 2015 he obtained a lectureship position at the University of Essex and was promoted to Senior Lecturer in 2020, before moving to King’s College in 2023.

Dr Prischi is a molecular biochemist whose work spans in vitro and in silico approaches to gain a greater understanding of protein regulation and stress responses. The overall aim of his research is to understand how the molecular machines that compose signalling pathways work together to transfer information in normal and stressed conditions. Unravelling protein regulation mechanisms is critical for advancing our understanding of disease progression and for the development of novel personalised treatments. His projects focus on (i) the functional and structural characterisation of the p70 and p90 Ribosomal S6 Kinase families and their complex regulation of RNA binding proteins, (ii) the development and use of high-throughput bioinformatics approaches coupled with structural biology methods to increase our understanding of protein dynamics and ligand binding.

Dr Prischi’s lab use a cutting-edge multi-disciplinary approach that combines biophysical, enzymatic, cellular and structural studies. Using X-ray crystallography, Nuclear Magnetic Resonance (NMR), Electron Microscopy (cryo-EM) coupled with Molecular Dynamics simulations (MD) they visualise macromolecules at atomic and near atomic resolution. At this scale they aim to dissect cellular processes at a molecular level and describe the details at the base of disease development, thereby providing a solid base for medical advance