Research output per year
Research output per year
Research output
- 7 Article
Search results
-
2021
MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia
Lin, Z., Kim, E., Ahmed, M., Han, G., Simmons, C., Redhead, Y., Bartlett, J., Pena Altamira, E., Callaghan, I., White, M., Singh, N., Sawiak, S., Spires-Jones, T., Vernon, A., Coleman, M. P., Green, J., Henstridge, C. M., Davies, J., Cash, D. & Sreedharan, J., 5 Apr 2021, In: Brain Communications. 3, 2, p. FCAB114 20 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
2020
Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice
watkins, J., Ghosh, A., keerie, A., alix, J., Mead, R. & Sreedharan, J., 20 Oct 2020, In: Scientific Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)55 Downloads (Pure) -
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
Weskamp, K., Tank, E. M., Miguez, R., McBride, J. P., Gómez, N. B., White, M., Lin, Z., Moreno Gonzalez, C., Serio, A., Sreedharan, J. & Barmada, S. J., 2 Mar 2020, In: Journal of Clinical Investigation. 130, 3, p. 1139-1155 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Citations (Scopus)265 Downloads (Pure) -
2019
Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116
Gowland, A., Opie-Martin, S., Scott, K. M., Jones, A. R., Mehta, P. R., Batts, C. J., Ellis, C. M., Leigh, P. N., Shaw, C. E., Sreedharan, J. & Al-Chalabi, A., 3 Apr 2019, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 3-4, p. 264-274 11 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
2018
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
White, M. A., Kim, E., Duffy, A., Adalbert, R., Phillips, B. U., Peters, O. M., Stephenson, J., Yang, S., Massenzio, F., Lin, Z., Andrews, S., Segonds-Pichon, A., Metterville, J., Saksida, L. M., Mead, R., Ribchester, R. R., Barhomi, Y., Serre, T., Coleman, M. P. & Fallon, J. & 3 others, , 19 Mar 2018, In: Nature Neuroscience. 21, p. 552–563Research output: Contribution to journal › Article › peer-review
Open AccessFile162 Citations (Scopus)139 Downloads (Pure) -
2015
Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2
Sreedharan, J., Neukomm, L. J., Brown, R. H. & Freeman, M. R., 17 Aug 2015, In: Current biology : CB. 25, 16, p. 2130-2136 7 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Citations (Scopus) -
2008
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., Baralle, F., de Belleroche, J., Mitchell, J. D., Leigh, P. N., Al-Chalabi, A., Miller, C. C., Nicholson, G. & Shaw, C. E., 21 Mar 2008, In: Science. 319, 5870, p. 1668-1672 5 p.Research output: Contribution to journal › Article › peer-review
2141 Citations (Scopus)