Search results

• 2022

  The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

  Krastev, D. B., Li, S., Sun, Y., Wicks, A. J., Hoslett, G., Weekes, D., Badder, L. M., Knight, E. G., Marlow, R., Pardo, M. C., Yu, L., Talele, T. T., Bartek, J., Choudhary, J. S., Pommier, Y., Pettitt, S. J., Tutt, A. N. J., Ramadan, K. & Lord, C. J., 10 Jan 2022, In: Nature Cell Biology. 24, 1, p. 62-73 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • P97 100%
  • PARP1 100%
  • Interactome 10%
  • Protein 10%
  • Small Molecule 10%
  84 Citations (Scopus)
• 2021

  Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

  Zatreanu, D., Robinson, H. M. R., Alkhatib, O., Boursier, M., Finch, H., Geo, L., Grande, D., Grinkevich, V., Heald, R. A., Langdon, S., Majithiya, J., McWhirter, C., Martin, N. M. B., Moore, S., Neves, J., Rajendra, E., Ranzani, M., Schaedler, T., Stockley, M. & Wiggins, K. & 41 others, Brough, R., Sridhar, S., Gulati, A., Shao, N., Badder, L. M., Novo, D., Knight, E. G., Marlow, R., Haider, S., Callen, E., Hewitt, G., Schimmel, J., Prevo, R., Alli, C., Ferdinand, A., Bell, C., Blencowe, P., Bot, C., Calder, M., Charles, M., Curry, J., Ekwuru, T., Ewings, K., Krajewski, W., MacDonald, E., McCarron, H., Pang, L., Pedder, C., Rigoreau, L., Swarbrick, M., Wheatley, E., Willis, S., Wong, A. C., Nussenzweig, A., Tijsterman, M., Tutt, A., Boulton, S. J., Higgins, G. S., Pettitt, S. J., Smith, G. C. M. & Lord, C. J., Dec 2021, In: Nature Communications. 12, 1, 3636.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BRCA Gene 100%
  • Polymerase 50%
  • Genetics 25%
  • Small Molecule 25%
  • Single-Stranded DNA 25%
  198 Citations (Scopus)
• 2020

  Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

  Yeow, Z. Y., Lambrus, B. G., Marlow, R., Zhan, K. H., Durin, M. A., Evans, L. T., Scott, P. M., Phan, T., Park, E., Ruiz, L. A., Moralli, D., Knight, E. G., Badder, L. M., Novo, D., Haider, S., Green, C. M., Tutt, A. N. J., Lord, C. J., Chapman, J. R. & Holland, A. J., 17 Sept 2020, In: Nature. 585, 7825, p. 447-452 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Genome Instability 100%
  • Genomics 50%
  • Small Molecule 24%
  • Pericentriolar Material 24%
  • Cancer Cell 24%
  68 Citations (Scopus)
• 2018

  Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer

  Cheung, A., Opzoomer, J. W., Ilieva, K. M., Gazinska, P., Hoffmann, R. M., Mirza, H., Marlow, R., Francesch-Domenech, E., Fittall, M. W., Dominguez Rodriguez, D., Clifford, A., Badder, L., Patel, N., Mele, S., Pellizzari, G., Bax, H. J., Crescioli, S., Petranyi, G., Larcombe-Young, D. & Josephs, D. H. & 9 others, Canevari, S., Figini, M., Pinder, S. E., Nestle, F. O., Gillett, C., Spicer, J., Grigoriadis, A., Tutt, A. & Karagiannis, S. N., 15 Oct 2018, In: Clinical Cancer Research. 24, 20, p. 5098-5111

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antifolate 100%
  • Triple Negative Breast Cancer 100%
  • Antibody Therapy 100%
  • Folate Receptor 1 100%
  • Folic Acid Antagonist 100%
  66 Citations (Scopus)

  239 Downloads (Pure)