Research output per year
Research output per year
Personal profile
Research interests
Psoriasis: analysis of molecular and immunological pathways of chronic inflammation; studies dissecting the molecular pathways of chronic inflammation in psoriasis using tissue samples' in vitro studies, and state-of-the-art in vivo models; genomic analysis of psoriasis tissue; investigation of the functional role of dendritic cells, conventional T cells and unconventional T cells in psoriasis; development of novel drug targets and testing in the clinic. Melanoma: analysis of molecular and immunological pathways in melanoma - studies on immune activation and immune escape in melanoma patients; dendritic cell targeting of tumour antigens; molecular analysis of melanoma tissues and cell lines; novel approaches to immunotherapy and molecular therapy of melanoma, including definition of biomarkers and mechanism-of-action studies. "http://www.kcl.ac.uk/schools/medicine/depts/dermatology/research/nestle/"
Research interests (short)
Analysis of molecular and immunological pathways in skin inflammation (psoriasis) and melanoma; development of novel therapeutics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4
Chauhan, J., Grandits, M., Palhares, L. C. G. F., Mele, S., Nakamura, M., López-Abente, J., Crescioli, S., Laddach, R., Romero-Clavijo, P., Cheung, A., Stavraka, C., Chenoweth, A. M., Sow, H. S., Chiaruttini, G., Gilbert, A. E., Dodev, T., Koers, A., Pellizzari, G., Ilieva, K. M. & Man, F. & 20 others, , 25 Apr 2023, In: Nature Communications. 14, 1, p. 2192Research output: Contribution to journal › Article › peer-review
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Anti-cancer Pro-inflammatory Effects of an IgE Antibody Targeting the Melanoma-associated Antigen Chondroitin Sulfate Proteoglycan 4
Chauhan, J., Grandits, M., Gusmao Ferreira, L. C., Mele, S., Nakamura, M., Lopez-Abente Muroz, J., Crescioli, S., Laddach, R., Romero Clavijo, P., Cheung, A., Stavraka, C., Chenoweth, A., Sow, H. S., Chiaruttini, G., Gilbert, A., Dodev, T., Koers, A., Pellizzari, G., Ilieva, K. & Man, F. & 20 others, , 25 Apr 2023, In: Nature Communications. 14, 1, 2192.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)232 Downloads (Pure) -
Human skin CD141+ dendritic cells regulate cutaneous immunity via the neuropeptide urocortin 2
Lui, P. P. W., Ainali, C., Chu, C. C., Terranova-Barberio, M., Karagiannis, P., Tewari, A., Safinia, N., Sharif-Paghaleh, E., Tsoka, S., Woszczek, G., Di Meglio, P., Lombardi, G., Young, A. R., Nestle, F. O. & Ali, N., 20 Oct 2023, In: iScience. 26, 10, 108029.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
MuTHER Consortium, Jan 2022, In: Nature genetics. 54, 1, p. 18-29 12 p.Research output: Contribution to journal › Article › peer-review
65 Citations (Scopus) -
Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation
Oláh, P., Szlávicz, E., Kuchner, M., Nemmer, J., Zeeuwen, P., Lefèvre-Utile, A., Fyhrquist, N., Prast-Nielsen, S., Skoog, T., Serra, A., Rodríguez, E., Raap, U., Meller, S., Gyulai, R., Hupé, P., Kere, J., Levi-Schaffer, F., Tsoka, S., Alexander, H. & Nestle, F. O. & 11 others, , Jun 2022, In: Journal of Dermatological Science. 106, 3, p. 132-140 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
Projects
- 51 Finished
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Investigating the role of the skin microbiome in healthy skin and psoriasis
Di Meglio, P. (Primary Investigator), Nestle, F. (Primary Investigator), Alwan, W. (Co-Investigator) & Barker, J. (Co-Investigator)
5/04/2017 → 1/02/2022
Project: Research
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CHECKMATE - Navigating the “autoimmunity – cancer” interface to decipher the cornerstone of immunity
Nestle, F. (Primary Investigator)
1/01/2017 → 31/12/2021
Project: Research
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Investigating the role of Lactobacillus Crispatus on the Aryl-hydrocarbon receptorpathway in normal skin and psoriasis
Nestle, F. (Primary Investigator) & Alwan, W. (Co-Investigator)
1/08/2016 → 1/08/2019
Project: Research
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Metagenomic analysis of the skin microbiome in atopic dermatitis and its interaction with the host transcriptome
Nestle, F. (Primary Investigator) & Alexander, H. (Co-Investigator)
1/08/2016 → 31/07/2019
Project: Research
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Metagenomic analysis of the skin microbe in atopic dermatitis and its interaction with host transcriptome
Nestle, F. (Primary Investigator) & Alexander, H. (Co-Investigator)
1/08/2016 → 31/07/2019
Project: Research