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Lynn Quek

Dr

 https://orcid.org/0000-0003-0221-5761
    • 4338
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    • 2021

      Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

      Crump, N. T., Hadjinicolaou, A. V., Xia, M., Walsby-Tickle, J., Gileadi, U., Chen, J.-L., Setshedi, M., Olsen, L. R., Lau, I.-J., Godfrey, L., Quek, L., Yu, Z., Ballabio, E., Barnkob, M. B., Napolitani, G., Salio, M., Koohy, H., Kessler, B. M., Taylor, S. & Vyas, P. & 3 others, McCullagh, J. S. O., Milne, T. A. & Cerundolo, V., 11 May 2021, In: Cell Reports. 35, 6, p. 109101 1 p., 109101.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      25 Citations (Scopus)
    • 2020

      Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML

      Choe, S., Wang, H., DiNardo, C. D., Stein, E. M., de Botton, S., Roboz, G. J., Altman, J. K., Mims, A. S., Watts, J. M., Pollyea, D. A., Fathi, A. T., Tallman, M. S., Kantarjian, H. M., Stone, R. M., Quek, L., Konteatis, Z., Dang, L., Nicolay, B., Nejad, P. & Liu, G. & 9 others, Zhang, V., Liu, H., Goldwasser, M., Liu, W., Marks, K., Bowden, C., Biller, S. A., Attar, E. C. & Wu, B., 12 May 2020, In: Blood Advances. 4, 9, p. 1894-1905 12 p.

      Research output: Contribution to journal › Article › peer-review

      132 Citations (Scopus)
    • 2018

      Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

      Quek, L., David, M. D., Kennedy, A., Metzner, M., Amatangelo, M., Shih, A., Stoilova, B., Quivoron, C., Heiblig, M., Willekens, C., Saada, V., Alsafadi, S., Vijayabaskar, M. S., Peniket, A., Bernard, O. A., Agresta, S., Yen, K., MacBeth, K., Stein, E. & Vassiliou, G. S. & 5 others, Levine, R., De Botton, S., Thakurta, A., Penard-Lacronique, V. & Vyas, P., 1 Aug 2018, In: Nature Medicine. 24, 8, p. 1167-1177 11 p.

      Research output: Contribution to journal › Article › peer-review

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      138 Citations (Scopus)
      90 Downloads (Pure)

    • Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells article

      Karamitros, D., Stoilova, B., Aboukhalil, Z., Hamey, F., Reinisch, A., Samitsch, M., Quek, L., Otto, G., Repapi, E., Doondeea, J., Usukhbayar, B., Calvo, J., Taylor, S., Goardon, N., Six, E., Pflumio, F., Porcher, C., Majeti, R., Göttgens, B. & Vyas, P., 1 Jan 2018, In: Nature Immunology. 19, 1, p. 85-97 13 p.

      Research output: Contribution to journal › Article › peer-review

      153 Citations (Scopus)
    • 2017

      Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

      Amatangelo, M. D., Quek, L., Shih, A., Stein, E. M., Roshal, M., David, M. D., Marteyn, B., Farnoud, N. R., de Botton, S., Bernard, O. A., Wu, B., Yen, K. E., Tallman, M. S., Papaemmanuil, E., Penard-Lacronique, V., Thakurta, A., Vyas, P. & Levine, R. L., 10 Aug 2017, In: Blood. 130, 6, p. 732-741 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
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      296 Citations (Scopus)
      151 Downloads (Pure)

    • Outcome of azacitidine therapy in acute myeloid leukemia is not improved by concurrent vorinostat therapy but is predicted by a diagnostic molecular signature

      Craddock, C. F., Houlton, A. E., Quek, L. S., Ferguson, P., Gbandi, E., Roberts, C., Metzner, M., Garcia-Martin, N., Kennedy, A., Hamblin, A., Raghavan, M., Nagra, S., Dudley, L., Wheatley, K., McMullin, M. F., Pillai, S. P., Kelly, R. J., Siddique, S., Dennis, M. & Cavenagh, J. D. & 1 others, Vyas, P., 1 Nov 2017, In: Clinical Cancer Research. 23, 21, p. 6430-6440 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      71 Citations (Scopus)
    • 2015

      Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

      Taylor, J. C., Martin, H. C., Lise, S., Broxholme, J., Cazier, J. B., Rimmer, A., Kanapin, A., Lunter, G., Fiddy, S., Allan, C., Aricescu, A. R., Attar, M., Babbs, C., Becq, J., Beeson, D., Bento, C., Bignell, P., Blair, E., Buckle, V. J. & Bull, K. & 90 others, Cais, O., Cario, H., Chapel, H., Copley, R. R., Cornall, R., Craft, J., Dahan, K., Davenport, E. E., Dendrou, C., Devuyst, O., Fenwick, A. L., Flint, J., Fugger, L., Gilbert, R. D., Goriely, A., Green, A., Greger, I. H., Grocock, R., Gruszczyk, A. V., Hastings, R., Hatton, E., Higgs, D., Hill, A., Holmes, C., Howard, M., Hughes, L., Humburg, P., Johnson, D., Karpe, F., Kingsbury, Z., Kini, U., Knight, J. C., Krohn, J., Lamble, S., Langman, C., Lonie, L., Luck, J., McCarthy, D., McGowan, S. J., McMullin, M. F., Miller, K. A., Murray, L., Németh, A. H., Nesbit, M. A., Nutt, D., Ormondroyd, E., Bang Oturai, A., Pagnamenta, A., Patel, S. Y., Percy, M., Petousi, N., Piazza, P., Piret, S. E., Polanco-Echeverry, G., Popitsch, N., Powrie, F., Pugh, C., Quek, L., Robbins, P. A., Robson, K., Russo, A., Sahgal, N., Van Schouwenburg, P. A., Schuh, A., Silverman, E., Simmons, A., Sorensen, P. S., Sweeney, E., Taylor, J., Thakker, R. V., Tomlinson, I., Trebes, A., Twigg, S. R. F., Uhlig, H. H., Vyas, P., Vyse, T., Wall, S. A., Watkins, H., Whyte, M. P., Witty, L., Wright, B., Yau, C., Buck, D., Humphray, S., Ratcliffe, P. J., Bell, J. I., Wilkie, A. O. M., Bentley, D., Donnelly, P. & McVean, G., 26 Jun 2015, In: Nature genetics. 47, 7, p. 717-726 10 p.

      Research output: Contribution to journal › Article › peer-review

      280 Citations (Scopus)
    • 2013

      Clinical and biological implications of driver mutations in myelodysplastic syndromes

      Papaemmanuil, E., Gerstung, M., Malcovati, L., Tauro, S., Gundem, G., Van Loo, P., Yoon, C. J., Ellis, P., Wedge, D. C., Pellagatti, A., Shlien, A., Groves, M. J., Forbes, S. A., Raine, K., Hinton, J., Mudie, L. J., McLaren, S., Hardy, C., Latimer, C. & Della Porta, M. G. & 18 others, O'Meara, S., Ambaglio, I., Galli, A., Butler, A. P., Walldin, G., Teague, J. W., Quek, L., Sternberg, A., Gambacorti-Passerini, C., Cross, N. C. P., Green, A. R., Boultwood, J., Vyas, P., Hellstrom-Lindberg, E., Bowen, D., Cazzola, M., Stratton, M. R. & Campbell, P. J., 21 Nov 2013, In: Blood. 122, 22, p. 3616-3627 12 p.

      Research output: Contribution to journal › Article › peer-review

      1492 Citations (Scopus)
    • 2011

      Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia

      Goardon, N., Marchi, E., Atzberger, A., Quek, L., Schuh, A., Soneji, S., Woll, P., Mead, A., Alford, K. A., Rout, R., Chaudhury, S., Gilkes, A., Knapper, S., Beldjord, K., Begum, S., Rose, S., Geddes, N., Griffiths, M., Standen, G. & Sternberg, A. & 14 others, Cavenagh, J., Hunter, H., Bowen, D., Killick, S., Robinson, L., Price, A., Macintyre, E., Virgo, P., Burnett, A., Craddock, C., Enver, T., Jacobsen, S. E. W., Porcher, C. & Vyas, P., 18 Jan 2011, In: CANCER CELL. 19, 1, p. 138-152 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      515 Citations (Scopus)
    • 2000

      Phosphatidylinositol 3,4,5-trisphosphate regulates Ca2+ entry via Btk in platelets and megakaryocytes without increasing phospholipase C activity

      Pasquet, J. M., Quek, L., Stevens, C., Bobe, R., Huber, M., Duronio, V., Krystal, G. & Watson, S. P., 15 Jun 2000, In: EMBO Journal. 19, 12, p. 2793-2802 10 p.

      Research output: Contribution to journal › Article › peer-review

      77 Citations (Scopus)
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