Panicos Shangaris

Dr Shangaris graduated from the Royal College of Surgeons in Ireland in 2005 and pursued higher specialist training in London at renowned institutions such as University College London (UCL), the Royal Free London, and North Middlesex Hospitals.

He enrolled in a Master's degree program at University College London (UCL), where he received a distinction in Fetal Medicine and Prenatal Genetics. Opting for deeper academic engagement, he embarked on a PhD at UCL. Under the supervision of Professor Anna David and Professor Paolo De Coppi, Dr Shangaris specialised in treating genetic blood disorders via fetal stem cell transplantation and gene therapy. Once he earned his PhD, Dr Shangaris took up a position as an NIHR Clinical Lecturer at King's College London (KCL). With a focus on Maternal and Fetal Medicine, he gained clinical experience at institutions such as Guy's and St Thomas' Hospitals and King's College Hospital (KCH).

Dr Shangaris currently holds the position of a Clinical Senior Lecturer and Consultant in Maternal and Fetal Medicine at King's College London and King’s College Hospital. His work has significantly advanced the field of prenatal therapy for sickle cell disease and the immunology of pregnancy. One of his major projects, the Prenatal Therapy for Sickle Cell Disease (PERICLES) project, focuses on developing and assessing gene-editing technologies and delivery methods in human and mouse fetal hematopoietic stem cells. This project aims to provide a therapeutic option that could lead to the birth of disease-free individuals, which is particularly transformative for regions where sickle cell disease is prevalent and treatment options are limited.

Sickle Cell Disease, Tregs in Pregnancy, In Utero Therapy, In Utero Gene Therapy, Haematopoietic Stem Cells