Search results

• 2015

  Preclinical Models of Graves' Disease and Associated Secondary Complications

  Moshkelgosha, S., So, P.-W., Diaz-Cano, S. & Banga, J. P., 2015, (E-pub ahead of print) In: Current Pharmaceutical Design. 21, 18, p. 2414-2421 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Graves Disease 100%
  • Mouse Model 42%
  • Experimental Mouse 14%
  • Hashimoto Disease 14%
  8 Citations (Scopus)
• 2013

  A redundant role for propeptide in human thyroid peroxidase protein for its cellular, enzymatic and immunological activity

  Godlewska, M., Góra, M., Buckle, A. M., Porebski, B. T., Kemp, E. H., Sutton, B. J., Czarnocka, B. & Banga, P. S., 2013, (E-pub ahead of print) In: Thyroid. -, -.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Glycosylation 16%
  • Crystallization 8%
  • Membrane 8%
  • Protein Catabolism 8%
  25 Citations (Scopus)

• Cutting Edge: Retrobulbar inflammation, adipogenesis, and acute orbital congestion in a preclinical female mouse model of Graves' orbitopathy induced by thyrotropin receptor plasmid-in vivo electroporation

  Moshkelgosha, S., So, P. W., Deasy, N., Diaz-Cano, S. & Banga, J. P., Sept 2013, In: Endocrinology. 154, 9, p. 3008-3015 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Female 100%
  • Endocrine Ophthalmopathy 100%
  • Inflammation 100%
  • Mouse Model 100%
  • Pathology 60%
  97 Citations (Scopus)

• Yersinia enterocolitica Provides the Link between Thyroid-Stimulating Antibodies and Their Germline Counterparts in Graves' Disease

  Hargreaves, C. E., Grasso, M., Hampe, C. S., Stenkova, A., Atkinson, S., Joshua, G. W. P., Wren, B. W., Buckle, A. M., Dunn-Walters, D. & Banga, J. P., 1 Jun 2013, In: Journal of Immunology. 190, 11, p. 5373-5381 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Germline 100%
  • Porin 66%
  • Protein 50%
  • Cross-Reactivity 22%
  • Genetics 16%
  64 Citations (Scopus)
• 2011

  Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints"

  Brix, T. H., Hegedus, L., Gardas, A., Banga, J. P. & Nielsen, C. H., May 2011, In: Autoimmunity. 44, 3, p. 188 - 194 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Hashimoto's Thyroiditis 100%
  • Autoantibodies 42%
  • Epitope 14%
  • Rabbit Antiserum 14%
  19 Citations (Scopus)

• Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA

  Zhao, S.-X., Tsui, S., Cheung, A., Douglas, R. S., Smith, T. J. & Banga, J. P., Sept 2011, In: Journal of Endocrinology. 210, 3, p. 369 - 377 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Grave's Disease 100%
  • Mouse Model 100%
  • Graves Disease 100%
  • Insulin-Like Growth Factor 1 Receptor 87%
  • In Vivo 12%
  65 Citations (Scopus)
• 2010

  Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function

  Padoa, C. J., Larsen, S. L., Hampe, C. S., Gilbert, J. A., Dagdan, E., Hegedus, L., Dunn-Walters, D. & Banga, J. P., Feb 2010, In: Immunology. 129, 2, p. 300 - 308 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin Light Chain 100%
  • Immunoglobulin Heavy Chain 100%
  • B Cell 20%
  • Somatic Hypermutation 20%
  2 Citations (Scopus)
• 2009

  Toward Better Models of Hyperthyroid Graves' Disease

  Dagdelen, S., Kong, Y.-C. M. & Banga, J. P., Jun 2009, In: Endocrinology and Metabolism Clinics of North America. 38, 2, p. 343 - + 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Graves Disease 100%
  • Antithyroid Agent 33%
  • Antithyroid Drugs 33%
  10 Citations (Scopus)

• Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies

  El Fassi, D., Banga, J. P., Gilbert, J. A., Padoa, C., Hegedus, L. & Nielsen, C. H., Mar 2009, In: CLINICAL IMMUNOLOGY. 130, 3, p. 252 - 258 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Methimazole 100%
  • Graves Disease 100%
  • Bioassay 33%
  74 Citations (Scopus)
• 2008

  COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity

  Fenalti, G., Hampe, C. S., Arafat, Y., Law, R. H. P., Banga, J. P., Mackay, I. R., Whisstock, J. C., Buckle, A. M. & Rowley, M. J., May 2008, In: Diabetes. 57, 5, p. 1293 - 1301 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Crystal Structure 40%
  • N-Terminus 20%
  • Solvent 20%
  • Mutagenesis 20%
  41 Citations (Scopus)

• Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis

  Nielsen, C. H., Brix, T. H., Gardas, A., Banga, J. P. & Hegedus, L., Oct 2008, In: Clinical endocrinology. 69, 4, p. 664 - 668 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Hashimoto's Thyroiditis 100%
  23 Citations (Scopus)

• Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies

  Hall, T. R., Bogdani, M., LeBoeuf, R. C., Kirk, E. A., Maziarz, M., Banga, J. P., Oak, S., Pennington, C. A. & Hampe, C. S., Apr 2008, In: Immunology. 123, 4, p. 547 - 554 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Antiidiotypic Antibody 100%
  • Autoantibodies 25%
  • Autoimmune Diabetes 25%
  15 Citations (Scopus)

• The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

  Oak, S., Gilliam, L. K., Landin-Olsson, M., Torn, C., Kockum, I., Pennington, C. R., Rowley, M. J., Christie, M. R., Banga, J. P. & Hampe, C. S., 8 Apr 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5471 - 5476 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Autoantibodies 100%
  • Antiidiotypic Antibody 100%
  • Glutamate Decarboxylase 100%
  • Radioimmunoassay 33%
  • Epitope 16%
  63 Citations (Scopus)
• 2007

  Application of HLA class II transgenic mice to study autoimmune regulation

  Kong, Y. C. M., Flynn, J. C., Banga, J. P. & David, C. S., 1 Oct 2007, In: Thyroid. 17, 10, p. 995 - 1003 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Thyroglobulin 100%
  • Transgenic Mouse 100%
  • Thyroiditis 100%
  • Experimental Autoimmune Thyroiditis 100%
  • Antibodies 66%
  15 Citations (Scopus)

• Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles

  Maruyama, T., Oak, S., Hall, T. R., Banga, J. P., Ortqvist, E., Ettinger, R. A., Endl, J. & Hampe, C. S., Dec 2007, In: Clinical and Experimental Immunology. 150, 3, p. 416 - 421 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Isoform 100%
  • Epitope 100%
  • Molecule 42%
  • Haplotype 28%
  • Reduction (Chemistry) 14%
  3 Citations (Scopus)

• Chronic exposure in vivo to thyrotropin receptor stimulating monoclonal antibodies sustains high thyroxine levels and thyroid hyperplasia in thyroid autoimmunity-prone HLA-DRB1*0301 transgenic mice

  Flynn, J. C., Gilbert, J. A., Meroueh, C., Snower, D. P., David, C. S., Kong, Y. M. & Banga, J. P., Oct 2007, In: Immunology. 122, 2, p. 261 - 267 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Transgenic Mouse 100%
  • Thyroid Gland 100%
  • Long Term Exposure 100%
  • In Vivo 100%
  • Thyrotropin Receptor 100%
  19 Citations (Scopus)

• GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

  Fenalti, G., Law, R., Buckle, A. M., Langendorf, C., Tuck, K., Rosado, C., Faux, N., Mahmood, K., Hampe, C., Banga, J. P., Wilce, M., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I., Rowley, M. & Whisstock, J. C., Apr 2007, In: NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 14, 4, p. 280 - 286 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Isoform 100%
  • N-Terminus 50%
  • Cofactors 50%
  • Kinetics 50%
  • Autoantigen 50%
  193 Citations (Scopus)
• 2006

  Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling

  O'Connor, K. H., Banga, J. P., Darmanin, C., El-Kabbani, O., Mackay, I. R. & Rowley, M. J., May 2006, In: Journal of Autoimmunity. 26, 3, p. 172 - 181 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Model 100%
  • Epitope 25%
  • Autoantibodies 25%
  • Paratope 25%
  • Bacteriophage 25%
  12 Citations (Scopus)

• Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11

  Fenalti, G., Hampe, C. S., O'Connor, K., Banga, J. P., Mackay, I. R., Rowley, M. J. & El-Kabbani, O., Feb 2006, In: Molecular Immunology. 44, 6, p. 1178 - 1189 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Autoantibodies 16%
  • Paratope 16%
  • Bacteriophage 16%
  • Antigenicity 16%
  16 Citations (Scopus)

• Monoclonal pathogenic antibodies to the thyroid-stimulating hormone receptor in Graves' disease with potent thyroid-stimulating activity but differential blocking activity activate multiple signaling pathways

  Gilbert, J. A., Gianoukakis, A. G., Salehi, S., Moorhead, J., Rao, P. V., Khan, M. Z., McGregor, A. M., Smith, T. J. & Banga, J. P., 15 Apr 2006, In: Journal of Immunology. 176, 8, p. 5084 - 5092 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor 100%
  • Graves' Disease 100%
  • Thyroid Gland 100%
  • Cell Signaling 100%
  • Grave's Disease 100%
  59 Citations (Scopus)

• Treatment of autoimmune hyperthyroidism in a murine model of Graves' disease with tumor necrosis factor-family ligand inhibitors suggests a key role for B cell activating factor in disease pathology

  Gilbert, J. A., Kalled, S. L., Moorhead, J., Hess, D. M., Rennert, P., Li, Z. F., Khan, M. Z. & Banga, J. P., 2006, In: Endocrinology. 147, 10, p. 4561 - 4568 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Necrosis Factor Family 100%
  • Graves Disease 100%
  • Grave's Disease 100%
  • Reduction (Chemistry) 27%
  • Animal 27%
  63 Citations (Scopus)
• 2005

  Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients

  Raju, R., Foote, J., Banga, J. P., Hall, T. R., Padoa, C. J., Dalakas, M. C., Ortqvist, E. & Hampe, C. S., 1 Dec 2005, In: Journal of Immunology. 175, 11, p. 7755 - 7762 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Autoantibodies 100%
  • Epitope 75%
  • B Cell 25%
  • Immunogenicity 25%
  • Linear Epitope 25%
  137 Citations (Scopus)

• Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes

  Schlosser, M., Banga, J., Madec, A., Binder, K., Strebelow, M., Rjasanowski, I., Wassmuth, R., Gilliam, L., Luo, D. & Hampe, C., May 2005, In: Diabetologia. 48, 5, p. 922 - 930 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Autoantibodies 100%
  • Autoimmunity 22%
  • Glutamate Decarboxylase 65 Antibody 22%
  58 Citations (Scopus)

• New insights into the conformational dominant epitopes on thyroid peroxidase recognized by human autoantibodies

  Bresson, D., Rebuffat, S. A., Nguyen, B., Banga, J. P., Gardas, A. & Peraldi-Roux, S., Jun 2005, In: Endocrinology. 146, 6, p. 2834 - 2844 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Autoantibodies 100%
  • Molecular Immunology 16%
  16 Citations (Scopus)
• 2004

  Development of a murine model of autoimmune thyroiditis induced with homologous mouse thyroid peroxidase

  Ng, H. P., Banga, J. P. & Kung, A. W., Feb 2004, In: Endocrinology. 145, 2, p. 809 - 816 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Murine 100%
  • Mouse Model 66%
  • Ectodomain 60%
  • Immune Response 33%
  • B Cell 33%
  49 Citations (Scopus)

• Dynamics of thyroid-stimulating and -blocking antibodies to the thyrotropin receptor in a murine model of Graves' disease

  Muehlberg, T., Gilbert, J. A., Rao, P. V., McGregor, A. M. & Banga, J. P., Apr 2004, In: Endocrinology. 145, 4, p. 1539 - 1545 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Thyrotropin Receptor 100%
  • Grave's Disease 100%
  • Blocking Antibody 100%
  • Epitope 50%
  • Autoantibodies 16%
  14 Citations (Scopus)

• Epitope analysis of GAD65Ab using fusion proteins and rFab

  Binder, K. A., Banga, J. P., Madec, A. M., Ortqvist, E., Luo, D. & Hampe, C. S., Dec 2004, In: Journal of Immunological Methods. 295, 1-2, p. 101 - 109 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Binding Antibody 100%
  • Autoantibodies 22%
  • Affinity Maturation 11%
  13 Citations (Scopus)

• Evaluation of conformational epitopes on thyroid peroxidase by antipeptide antibody binding and mutagenesis

  Gora, M., Gardas, A., Wiktorowicz, W., Hobby, P., Watson, P. F., Weetman, A. P., Sutton, B. J. & Banga, J. P., Apr 2004, In: Clinical and Experimental Immunology. 136, 1, p. 137 - 144 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Binding Antibody 100%
  • Autoantibodies 50%
  • Antiserum 50%
  • Epitope 33%
  • Complement Control Protein 16%
  26 Citations (Scopus)

• Induction of hyperthyroidism in mice by intradermal immunization with DNA encoding the thyrotropin receptor

  Barrett, K., Liakata, E., Rao, P. V., Watson, P. F., Weetman, A. P., Lymberi, P., Banga, J. P. & Carayanniotis, G., Jun 2004, In: Clinical and Experimental Immunology. 136, 3, p. 413 - 422 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Thyrotropin Receptor 100%
  • Grave's Disease 100%
  • Graves Disease 100%
  • Animal 75%
  • Inbred Mouse Strain 50%
  21 Citations (Scopus)

• Key residues contributing to dominant conformational autoantigenic epitopes on thyroid peroxidase identified by mutagenesis

  Gora, M., Gardas, A., Watson, P. F., Hobby, P., Weetman, A. P., Sutton, B. J. & Banga, J. P., 30 Jul 2004, In: Biochemical and Biophysical Research Communications. 320, 3, p. 795 - 801 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Autoantibodies 60%
  17 Citations (Scopus)

• Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient.

  Banga, J. P., Moore, J. K., Duhindan, N., Madec, A. M., van Endert, P. M., Orgiazzi, J. & Endl, J., Jan 2004, In: Clinical and Experimental Immunology. 135, 1, p. 74 - 84 11 p.

  Research output: Contribution to journal › Article › peer-review

  • B Cell 100%
  • Epitope 57%
  • Antigen 42%
  • Autoantibodies 14%
  • HLA-DM 14%
  25 Citations (Scopus)

• Multiplicity of the antibody response to GAD65 in Type I diabetes

  Gilliam, L. K., Binder, K. A., Banga, J. P., Madec, A. M., Ortqvist, E., Kockum, I., Luo, D. & Hampe, C. S., Nov 2004, In: Clinical and Experimental Immunology. 138, 2, p. 337 - 341 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Decarboxylase 65 Antibody 100%
  • Epitope 33%
  • Autoantibodies 33%
  14 Citations (Scopus)

• Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice

  Flynn, J. C., Gardas, A., Wan, Q., Gora, M., Alsharabi, G., Wei, W. Z., Giraldo, A. A., David, C. S., Kong, Y. M. & Banga, J. P., Sept 2004, In: Clinical and Experimental Immunology. 137, 3, p. 503 - 512 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Transgenic Mouse 100%
  • Thyroiditis 100%
  • Autoimmunity 100%
  • Experimental Autoimmune Thyroiditis 50%
  • Pig 33%
  22 Citations (Scopus)

• The development of new density gradient media for purifying human islets and islet-quality assessments

  Huang, G. C., Zhao, M., Jones, P., Persaud, S., Ramracheya, R., Lobner, K., Christie, M. R., Banga, J. P., Peakman, M., Sirinivsan, P., Rela, M., Heaton, N. & Amiel, S., 15 Jan 2004, In: Transplantation. 77, 1, p. 143 - 145 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Islet Transplantation 100%
  • Medium 100%
  • Yield 60%
  • Diabetes Mellitus 50%
  • Pancreas 50%
  100 Citations (Scopus)
• 2003

  Contrasting activities of thyrotropin receptor antibodies in experimental models of Graves' disease induced by injection of transfected fibroblasts or deoxyribonucleic acid vaccination

  Rao, P. V., Watson, P. F., Weetman, A. P., Carayanniotis, G. & Banga, J. P., 1 Jan 2003, In: Endocrinology. 144, 1, p. 260 - 266 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Vaccination 100%
  • Thyrotropin Receptor Antibody 100%
  • Graves Disease 100%
  • Blocking Antibody 50%
  • Plasmid 50%
  40 Citations (Scopus)

• Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs

  Padoa, C. J., Banga, J. P., Madec, A. M., Ziegler, M., Schlosser, M., Ortqvist, E., Kockum, I., Palmer, J., Rolandsson, O., Binder, K. A., Foote, J., Luo, D. & Hampe, C. S., Nov 2003, In: Diabetes. 52, 11, p. 2689 - 2695 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Epitope 100%
  • Autoimmune Diabetes 40%
  • Competition 40%
  • Autoantibodies 20%
  74 Citations (Scopus)
• 2001

  Role of complex asparagine-linked oligosaccharides in the expression of a functional thyrotropin receptor.

  Siffroi-Fernandez, S., Costagliola, S., Paumel, S., Ciraud, A., Banga, J. P. & Franc, J. L., 1 Mar 2001, In: THE BIOCHEMICAL JOURNAL. 354, 2, p. 331 - 336 6 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)
• 1990

  A simple high yield method for the preparation of lambda gt10 DNA suitable for subcloning, amplification and direct sequencing

  Malik, A. N., McLean, P. M., Roberts, A., Barnett, P. S., Demaine, A. G., Banga, J. P. & McGregor, A. M., 11 Jul 1990, In: Nucleic Acids Research. 18, 13, p. 4031-4032 2 p., N/A.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Citations (Scopus)