Search results

• 2021

  Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

  Zatreanu, D., Robinson, H. M. R., Alkhatib, O., Boursier, M., Finch, H., Geo, L., Grande, D., Grinkevich, V., Heald, R. A., Langdon, S., Majithiya, J., McWhirter, C., Martin, N. M. B., Moore, S., Neves, J., Rajendra, E., Ranzani, M., Schaedler, T., Stockley, M. & Wiggins, K. & 41 others, Brough, R., Sridhar, S., Gulati, A., Shao, N., Badder, L. M., Novo, D., Knight, E. G., Marlow, R., Haider, S., Callen, E., Hewitt, G., Schimmel, J., Prevo, R., Alli, C., Ferdinand, A., Bell, C., Blencowe, P., Bot, C., Calder, M., Charles, M., Curry, J., Ekwuru, T., Ewings, K., Krajewski, W., MacDonald, E., McCarron, H., Pang, L., Pedder, C., Rigoreau, L., Swarbrick, M., Wheatley, E., Willis, S., Wong, A. C., Nussenzweig, A., Tijsterman, M., Tutt, A., Boulton, S. J., Higgins, G. S., Pettitt, S. J., Smith, G. C. M. & Lord, C. J., Dec 2021, In: Nature Communications. 12, 1, 3636.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BRCA Gene 100%
  • Polymerase 50%
  • Genetics 25%
  • Small Molecule 25%
  • Single-Stranded DNA 25%
  184 Citations (Scopus)
• 2020

  Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

  Yeow, Z. Y., Lambrus, B. G., Marlow, R., Zhan, K. H., Durin, M. A., Evans, L. T., Scott, P. M., Phan, T., Park, E., Ruiz, L. A., Moralli, D., Knight, E. G., Badder, L. M., Novo, D., Haider, S., Green, C. M., Tutt, A. N. J., Lord, C. J., Chapman, J. R. & Holland, A. J., 17 Sept 2020, In: Nature. 585, 7825, p. 447-452 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Genome Instability 100%
  • Genomics 50%
  • Small Molecule 24%
  • Pericentriolar Material 24%
  • Cancer Cell 24%
  64 Citations (Scopus)
• 2019

  Integrin-mediated macrophage adhesion promotes lymphovascular dissemination in breast cancer

  Evans, R., Flores-Borja, F., Nassiri, S., Miranda, E., Lawler, K., Grigoriadis, A., Monypenny, J., Gillett, C., Owen, J., Gordon, P., Male, V., Cheung, A., Noor, F., Barber, P., Marlow, R., Francesch-Domenech, E., Fruhwirth, G., Squadrito, M., Vojnovic, B. & Tutt, A. & 3 others, Festy, F., De Palma, M. & Ng, T., 14 May 2019, In: Cell Reports. 27, 7, p. 1967-1978.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breast Cancer 100%
  • Macrophage 100%
  • Lymph Duct 100%
  • Metastatic Carcinoma 45%
  • Drive 27%
  39 Citations (Scopus)

  262 Downloads (Pure)
• 2018

  E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

  Bajrami, I., Marlow, R., van de Ven, M., Brough, R., Pemberton, H. N., Frankum, J., Song, F., Rafiq, R., Konde, A., Krastev, D. B., Menon, M., Campbell, J., Gulati, A., Kumar, R., Pettitt, S. J., Gurden, M. D., Cardenosa, M. L., Chong, I., Gazinska, P. & Wallberg, F. & 11 others, Sawyer, E. J., Martin, L.-A., Dowsett, M., Linardopoulos, S., Natrajan, R., Ryan, C. J., Derksen, P. W. B., Jonkers, J., Tutt, A. N. J., Ashworth, A. & Lord, C. J., 4 Apr 2018, In: Cancer discovery. 8, 4, p. 498-515

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ROS1 100%
  • Clinical Trial 20%
  • Glycoprotein E 20%
  • Foretinib 20%
  • Phosphorylation 12%
  87 Citations (Scopus)

  217 Downloads (Pure)