Investigation into the molecular mechanisms underlying pulmonary arterial disease; functional characterization of TGF-beta; cell signaling in vascular cells; identification of candidate susceptibility genes in the common skin disease psoriasis; genome-wide linkage analysis in familial cluster headache; functional characterization of human developmental disease genes, identified through homozygosity mapping in a range of autosomal recessive disorders; management of the National Autozygosity Mapping Resource (NAMR). Identification of major and minor susceptibility genes for psoriasis, using genome-wide linkage analysis, SNP-based approaches, construction and refinement of susceptibility haplotypes (with ProfessorJonathan Barker); functional role of psoriasis susceptibility genes (with ProfessorAdrian Hayday/Professor Frank Nestle); candidate gene approach to susceptibility gene identification in atopic dermatitis (with Professor Jonathan Barker). Identification of susceptibility loci in psoriasis.

Pulmonary arterial disease, common complex disease genetics, mapping in autosomal recessive disorders