Professor Hider’s interest in medicinal chemistry is focused on the mechanics of the movement of iron both within cells and across membranes. He has worked with siderophore-based iron uptake processes in micro-organisms, plant root absorption of iron and the absorption of different molecular forms of iron by mammalian cells, including gastrointestinal enterocytes, hepatocytes, macrophages, myocytes and reticulocytes. This work has led to the development of novel oral iron chelators for the treatment of iron overload. Hider synthesised a range of iron chelators, all designed to permeate cell membranes in both the iron-free and iron-complexed form. This systematic analysis took place in the early 1980’s and identified N-alkyl-3-hydroxypyridin-4-ones as having potential for clinical application.

http://www.kcl.ac.uk/biohealth/research/divisions/ips/about/people/Hider/Hiderresearch.pdf

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