Research output per year
Research output per year
Personal profile
Research interests
Lab interests include developmental genetics of striated muscle and its attachments and innervation in vertebrates, studied using zebrafish and mice; control of muscle cell size and character in the adult; the role of force in muscle growth and maintenance; morphogenesis; prevention of ageing-related muscle atrophy; comparative evolution of neuromuscular system; muscle repair in disease and after injury; cardiac growth and repair; myocardial cell proliferation, differentiation and growth; trabeculation; regulation of protein synthesis by TOR singalling; Dystrophin and associated proteins involved in muscular dystrophies.
Our work has focused on elucidating the genes/proteins regulating defined steps in muscle development or processes in adult muscle. Gene families of specific interest have been Hedgehog, Fgf, Wnt, Myod, Mef2, Pax3/7, p57kip2/cdkn1c, Tbx, eIF4EBP, Mtor, Tead.
Research interests (short)
Development and growth of muscle and its attachments; cardiac growth and repair; zebrafish; mechanobiology; stem cells; ageing; neuromuscular interaction; cell biology; evolution
Click here for the Hughes group webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Visual transduction in retinal rod cells, University of Cambridge
Award Date: 1 Jan 1984
Master of Arts, University of Cambridge
Award Date: 1 Jan 1983
Master of Philosophy, Measurement of free divalent cations in cells and organelles, University of Cambridge
Award Date: 1 Jan 1981
External positions
External Scientific Staff, MRC Medical Research Council
1 Jul 1992 → …
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Collaborations and top research areas from the last five years
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Research output
- 10 Article
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Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis
Ganassi, M., Badodi, S., Wanders, K., Zammit, P. S. & Hughes, S. M., 30 Oct 2020, In: eLife. 9, p. 1-23 23 p., e60445.Research output: Contribution to journal › Article › peer-review
Open AccessFile85 Citations (Scopus)129 Downloads (Pure) -
Myogenin promotes myocyte fusion to balance fibre number and size
Ganassi, M., Badodi, S., Ortuste Quiroga, H. P., Zammit, P. S., Hinits, Y. & Hughes, S. M., 12 Oct 2018, In: Nature Communications. 9, p. 1-17 4232.Research output: Contribution to journal › Article › peer-review
Open AccessFile114 Citations (Scopus)296 Downloads (Pure) -
In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis
Bajanca, F., Gonzalez-Perez, V., Gillespie, S. J., Beley, C., Garcia, L., Theveneau, E., Sear, R. P. & Hughes, S. M., 13 Oct 2015, In: eLife. 4, p. 1-32 32 p., e06541.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish
Pascoal, S., Esteves de Lima, J., Leslie, J. D., Hughes, S. M. & Saude, L., 28 Jun 2013, In: PL o S One . 8, 6, p. N/A 10 p., e68021.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Cooperation between Shh and IGF-I in promoting myogenic proliferation and differentiation via the MAPK/ERK and PI3K/Akt pathways requires smo activity
Madhala-Levy, D., Williams, V. C., Hughes, S. M., Reshef, R. & Halevy, O., Apr 2012, In: Journal of Cellular Physiology. 227, 4, p. 1455 - 1464 10 p.Research output: Contribution to journal › Article › peer-review
44 Citations (Scopus)