Research output per year
Research output per year
- 16 results
Search results
-
2017
FLT3 and JAK2 mutations in acute myeloid leukemia promote interchromosomal homologous recombination and the potential for copy neutral loss of heterozygosity
Gaymes, T. J., Mohamedali, A., Eiliazadeh, A. L., Darling, D. & Mufti, G. J., Apr 2017, In: Cancer Research. 77, 7, p. 1697-1708 12 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients
Shall, S., Gaymes, T., Farzaneh, F., Curtin, N. J. & Mufti, G., 11 Jul 2017, (E-pub ahead of print) Poly(ADP-Ribose) Polymerase: Methods and Protocols. Springer, Vol. 1608. p. 343-370 28 p. (Methods in Molecular Biology (MIMB); vol. 1608).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
6 Citations (Scopus) -
2013
Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies
Gaymes, T., Mohamedali, A. M., Patterson, M., Matto, N., Smith, A., Kulasekararaj, A., Chelliah, R., Curtin, N., Farzaneh, F., Shall, S. & Mufti, G. J., Sept 2013, In: Haematologica. 98, 9, p. 1397-1406 10 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
2011
Microsatellite Instability Induced Mutation in DNA Repair Genes, CTiP and Mre11 Confer Hypersensitivity to PARP Inhibitors in Myeloid Malignancies
Gaymes, T. J., Chelliah, R., Kulasekararaj, A. G., Mohamedali, A. M., Shall, S. & Mufti, G. J., 2011, In: Blood. 118, 21, p. 127 - 127 1 p.Research output: Contribution to journal › Meeting abstract
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The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy; Use as a Single Agent in Susceptible Patients; Techniques Used to Identify Susceptible Patients
Shall, S., Gaymes, T., Farzaneh, F., Curtin, N. & Mufti, G. J., 2011, In: Methods in Molecular Biology. 780, p. 239-266 28 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
2010
Microsatellite Instability (MSI) In High Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Cells Promotes Frameshift Mutations In DNA Repair Genes: Indications for PARP Inhibitor Therapy.
Gaymes, T. J., Mohamedali, A., Kulasekararaj, A. G., Shall, S. & Mufti, G. J., 2010, In: Blood. 116, 21, p. 513 - 513 1 p.Research output: Contribution to journal › Meeting abstract
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Polycomb Complex Group Gene Mutations and Their Prognostic Relevance In 5-Azacitidine Treated Myelodysplastic Syndrome Patients
Kulasekararaj, A. G., Mohamedali, A. M., Smith, A. E., Lea, N. C., Kizilors, A., Abdallah, A., Nasser, E. E., Mian, S. A., Yiu, R., Gaken, J., Pomplun, S., Jiang, J., Gaymes, T. J., Pasipanodya, P., Hayden, J., Ireland, R. M., Lim, Z. Y., Ho, A. Y., Marsh, J. C. W. & Mufti, G. J., 2010, In: Blood. 116, 21, p. 61 - 61 1 p.Research output: Contribution to journal › Meeting abstract
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Reducing MCM levels in human primary T cells during the G(0)-> G(1) transition causes genomic instability during the first cell cycle
Orr, S. J., Gaymes, T., Ladon, D., Chronis, C., Czepulkowski, B., Wang, R., Mufti, G. J., Marcotte, E. M. & Thomas, N. S. B., 1 Jul 2010, In: Oncogene. 29, 26, p. 3803 - 3814 12 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
2007
Reactive oxygen species, DNA damage, and error-prone repair: A model for genomic instability with progression in myeloid leukemia?
Rassool, F., Gaymes, T. J., Omidvar, N., Brady, N., Beurlet, S., Pla, M., Reboul, M., Lea, N., Chomienne, C., Thomas, N. S. B., Mufti, G. & Padua, R. A., 15 Sept 2007, In: Cancer Research. 67, 18, p. 8762 - 8771 10 p.Research output: Contribution to journal › Article › peer-review
136 Citations (Scopus) -
2006
Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?
Gaymes, T., Padua, R., Pla, M., Orr, S., Omidvar, N., Chomienne, C., Mufti, G. & Rassool, F., Aug 2006, In: MOLECULAR CANCER RESEARCH. 4, 8, p. 563 - 573 11 p.Research output: Contribution to journal › Article › peer-review
93 Citations (Scopus) -
2003
Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins
Brady, N., Gaymes, T. J., Cheung, M. Y., Mufti, G. J. & Rassool, F. V., 15 Apr 2003, In: Cancer Research. 63, 8, p. 1798 - 1805 8 p.Research output: Contribution to journal › Article › peer-review
71 Citations (Scopus) -
2002
Increased error-prone non homologous DNA end-joining - a proposed mechanism of chromosomal instability in Bloom's syndrome
Gaymes, T. J., North, P. S., Brady, N., Hickson, I. D., Mufti, G. J. & Rassool, F. V., 2002, In: Oncogene. 21, 16, p. 2525 - 2533 9 p.Research output: Contribution to journal › Article › peer-review
88 Citations (Scopus) -
Increased NHEJ activity in myeloid leukemias is associated with ongoing or induced DNA damage at sites that recruit key NHEJ proteins.
Brady, N., Gaymes, T. J., Cheung, M., Mufti, G. J. & Rassool, F. V., 2002, In: Blood. 100, 11, p. 4253 1 p.Research output: Contribution to journal › Meeting abstract
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Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer
Gaymes, T. J., Mufti, G. J. & Rassool, F. V., 15 May 2002, In: Cancer Research. 62, 10, p. 2791 - 2797 7 p.Research output: Contribution to journal › Article › peer-review
108 Citations (Scopus) -
2001
Increased activity and infidelity of non homologous end-joining (NHEJ) DNA repair in Bloom's syndrome and myeloid leukemias (MDS/AML).
Gaymes, T. J., North, P. S., Hickson, I. D., Pagliuca, A., Mufti, G. J. & Rassool, F. V., 2001, In: Blood. 98, 11, p. 455A - 455AResearch output: Contribution to journal › Meeting abstract
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2000
Increased non homologous and joining (NHEJ) efficiency and infidelity in myeloid leukaemia: A possible mechanism for chromosomal deletions in cancer.
Gaymes, T. J., Mufti, G. J. & Rassool, F. V., 2000, In: Blood. 96, 11, p. 158B - 159BResearch output: Contribution to journal › Meeting abstract