Research output per year
Research output per year
Personal profile
Research interests
The main aim of our research is to understand gene networks using computational methods. We use large-scale datasets that can be represented as graphs (networks), such as protein-protein interaction data, transcription factor localisation data and microarray data. The number of organisms for which such large-scale datasets are available is increasing rapidly. Combining these data sets helps to get a picture of the 'real' network in the cell. We use these datasets to explore the function of individual genes and their interaction partners as well as attempt to identify genes involved in disease processes.
Research interests (short)
Understanding gene networks using computational methods
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
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Network-informed gene ranking tackles genetic heterogeneity in exome-sequencing studies of monogenic disease
Dand, N., Schulz, R., Weale, M. E., Southgate, L., Oakey, R. J., Simpson, M. A. & Schlitt, T., 1 Dec 2015, In: Human Mutation. 36, 12, p. 1135-1144 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)203 Downloads (Pure) -
Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes
Prescott, N. J., Lehne, B., Stone, K., Lee, J. C., Taylor, K., Knight, J., Papouli, E., Mirza, M. M., Simpson, M. A., Spain, S. L., Lu, G., Fraternali, F., Bumpstead, S. J., Gray, E., Amar, A., Bye, H., Green, P., Chung-Faye, G., Hayee, B. & Pollok, R. & 10 others, , 11 Feb 2015, In: PL o S Genetics. 11, 2, 19 p., e1004955.Research output: Contribution to journal › Article › peer-review
Open Access48 Citations (Scopus) -
BioGranat-IG: a network analysis tool to suggest mechanisms of genetic heterogeneity from exome-sequencing data
Dand, N., Sprengel, F., Ahlers, V. & Schlitt, T., 15 Mar 2013, In: Bioinformatics (Oxford, England). 29, 6, p. 733-741 9 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Predicting the functional consequences of non-synonymous DNA sequence variants - evaluation of bioinformatics tools and development of a consensus strategy
Frousios, K., Iliopoulos, C. S., Schlitt, T. & Simpson, M. A., Oct 2013, In: Genomics. 102, 4, p. 223-228 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)201 Downloads (Pure) -
Exome localization of complex disease association signals
Lehne, B., Lewis, C. M. & Schlitt, T., 1 Feb 2011, In: BMC GENOMICS. 12, 92.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus)
Projects
- 10 Finished
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Post GWAS: a functional genomic analysis of the SLE susceptibility gene IKZF1
Cunninghame Graham, D. (Primary Investigator), Morris, D. (Co-Investigator), Schlitt, T. (Co-Investigator) & Vyse, T. (Co-Investigator)
1/01/2013 → 31/10/2017
Project: Research
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Novel bioinformatics methods fro the identification of sequence variants with phenotypic effects using biological networks and pathways
Schlitt, T. (Primary Investigator)
1/01/2013 → 31/12/2015
Project: Research
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NATURIMMUN: Natural Killer Cell Based Anti-Cancer Immunotherapies: Research training in molecular medicine and biotechnology business (NATURIMMUN)
Schlitt, T. (Primary Investigator)
1/10/2012 → 30/09/2016
Project: Research
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Assessing effect of dietary interventions on multiple organ systems by molecular profiling
Antoniou, M. (Primary Investigator) & Schlitt, T. (Co-Investigator)
1/07/2012 → 31/03/2016
Project: Research
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Systems-biology based approaches for the identification of genes controlling complex phenotypic traits
Dobson, R. (Primary Investigator), Schlitt, T. (Primary Investigator) & Lewis, C. (Co-Investigator)
1/10/2011 → 30/09/2015
Project: Research
Activities
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Program Committee for the Asian Pacific Conference on Bioinformatics
Schlitt, T. (Member)
2008 → …Activity: Other › Types of External academic engagement - Membership of peer review panel or committee
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the London Bioinformatics Meeting
Schlitt, T. (Organiser)
2007 → …Activity: Participating in or organising an event › Participation in conference
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European Conference on Bioinformatics ECCB
Schlitt, T. (Speaker)
2002 → …Activity: Participating in or organising an event › Participation in conference
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the Newton Institute, Cambrigde
Schlitt, T. (Member)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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GENOME BIOLOGY (Journal)
Schlitt, T. (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review