Search results

• 2024

  Disrupting Na⁺ ion homeostasis and Na⁺/K⁺ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo.

  Michaels, A. M., Zoccarato, A., Hoare, Z., Firth, G., Chung, Y. J., Kuchel, P. W., Shah, A. M., Shattock, M. J., Southworth, R. & Eykyn, T. R., 24 May 2024, In: Cancer & metabolism. 12, 1, p. 15

  Research output: Contribution to journal › Article › peer-review

  • Cancer Cell 100%
  • Breast Cancer 100%
  • In Vitro 100%
  • Sodium Ion 100%
  • Adenosine Triphosphatase (Potassium) 100%

• Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart: Intracellular Na reversibly alters myocardial metabolism and energetics

  Chung, Y. J., Hoare, Z., Baark, F., Yu, C. S., Gun, J., Fuller, W., Southworth, R., Katschinski, D. M., Murphy, M. P., Eykyn, T. & Shattock, M., 20 May 2024, In: Nature Communications. 15, 1, 4277.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Congestive Heart Failure 100%
  • Therapeutic Procedure 50%
  • Hypoxia 50%
  • Myosin 50%
  • Sodium 50%
  2 Citations (Scopus)
• 2023

  Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening

  Parijat, P., Attili, S., Hoare, Z., Shattock, M., Kenyon, V. & Kampourakis, T., 13 Nov 2023, In: Nature Communications.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  151 Downloads (Pure)