A comparison of 18F-dopa PET and inversion recovery MRI in the diagnosis of parkinson's disease

M. T M Hu; S. J. White; A. H. Herlihy; K. R. Chaudhuri; J. V. Hajnal; D. J. Brooks

doi:10.​1212/​WNL.​56.​9.​1195

A comparison of ¹⁸F-dopa PET and inversion recovery MRI in the diagnosis of parkinson's disease

M. T M Hu^*, S. J. White, A. H. Herlihy, K. R. Chaudhuri, J. V. Hajnal, D. J. Brooks

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Objective: To quantify structural changes in the substantia nigra of patients with PD with inversion recovery MRI and to compare these with striatal dopaminergic function measured with ¹⁸SF-dopa PET.

Methods: The authors studied 10 patients with PD and eight age-matched control subjects with a combination of MR sequences previously reported to be sensitive to nigral cell loss. Striatal regions of interest were defined on T1-weighted MRI coregistered to ¹⁸SF-dopa PET in all subjects. Results: Discriminant function analysis of the quantified MR nigral signal correctly classified 83% of the combined PD patient/control group; three of 10 PD cases were incorrectly classified as "normal" (Wilks' λ = 0.724, p > 0.05). Discriminant function analysis correctly classified 100% of PD patients and control subjects with ¹⁸SF-dopa PET based on mean caudate and putamen K_i values (Wilks' λ = 0.065, p < 0.001). Correlations between mean putamen K_i and rostral and caudal nigral MR signal changes and mean caudate K_i and caudal nigral MR signal changes were found (r = -0.76, -0.69, -0.80, p < 0.05).

Conclusion: ¹⁸F-dopa PET is more reliable than inversion recovery MRI in discriminating patients with moderately severe PD from normal subjects. However, the structural changes detected within the substantia nigra of patients with PD found using inversion recovery MRI correlate with measures of striatal dopaminergic function using ¹⁸F-dopa PET.

Original language	English
Pages (from-to)	1195-1200
Number of pages	6
Journal	Neurology
Volume	56
Issue number	9
DOIs	https://doi.org/10.1212/WNL.56.9.1195
Publication status	Published - 8 May 2001

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10.1212/WNL.56.9.1195

http://www.neurology.org/content/56/9/1195.short

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title = "A comparison of 18F-dopa PET and inversion recovery MRI in the diagnosis of parkinson's disease",

abstract = "Objective: To quantify structural changes in the substantia nigra of patients with PD with inversion recovery MRI and to compare these with striatal dopaminergic function measured with 18SF-dopa PET. Methods: The authors studied 10 patients with PD and eight age-matched control subjects with a combination of MR sequences previously reported to be sensitive to nigral cell loss. Striatal regions of interest were defined on T1-weighted MRI coregistered to 18SF-dopa PET in all subjects. Results: Discriminant function analysis of the quantified MR nigral signal correctly classified 83% of the combined PD patient/control group; three of 10 PD cases were incorrectly classified as {"}normal{"} (Wilks' λ = 0.724, p > 0.05). Discriminant function analysis correctly classified 100% of PD patients and control subjects with 18SF-dopa PET based on mean caudate and putamen Ki values (Wilks' λ = 0.065, p < 0.001). Correlations between mean putamen Ki and rostral and caudal nigral MR signal changes and mean caudate Ki and caudal nigral MR signal changes were found (r = -0.76, -0.69, -0.80, p < 0.05). Conclusion: 18F-dopa PET is more reliable than inversion recovery MRI in discriminating patients with moderately severe PD from normal subjects. However, the structural changes detected within the substantia nigra of patients with PD found using inversion recovery MRI correlate with measures of striatal dopaminergic function using 18F-dopa PET.",

author = "Hu, {M. T M} and White, {S. J.} and Herlihy, {A. H.} and Chaudhuri, {K. R.} and Hajnal, {J. V.} and Brooks, {D. J.}",

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AU - Hu, M. T M

AU - White, S. J.

AU - Herlihy, A. H.

AU - Chaudhuri, K. R.

AU - Hajnal, J. V.

AU - Brooks, D. J.

PY - 2001/5/8

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N2 - Objective: To quantify structural changes in the substantia nigra of patients with PD with inversion recovery MRI and to compare these with striatal dopaminergic function measured with 18SF-dopa PET. Methods: The authors studied 10 patients with PD and eight age-matched control subjects with a combination of MR sequences previously reported to be sensitive to nigral cell loss. Striatal regions of interest were defined on T1-weighted MRI coregistered to 18SF-dopa PET in all subjects. Results: Discriminant function analysis of the quantified MR nigral signal correctly classified 83% of the combined PD patient/control group; three of 10 PD cases were incorrectly classified as "normal" (Wilks' λ = 0.724, p > 0.05). Discriminant function analysis correctly classified 100% of PD patients and control subjects with 18SF-dopa PET based on mean caudate and putamen Ki values (Wilks' λ = 0.065, p < 0.001). Correlations between mean putamen Ki and rostral and caudal nigral MR signal changes and mean caudate Ki and caudal nigral MR signal changes were found (r = -0.76, -0.69, -0.80, p < 0.05). Conclusion: 18F-dopa PET is more reliable than inversion recovery MRI in discriminating patients with moderately severe PD from normal subjects. However, the structural changes detected within the substantia nigra of patients with PD found using inversion recovery MRI correlate with measures of striatal dopaminergic function using 18F-dopa PET.

AB - Objective: To quantify structural changes in the substantia nigra of patients with PD with inversion recovery MRI and to compare these with striatal dopaminergic function measured with 18SF-dopa PET. Methods: The authors studied 10 patients with PD and eight age-matched control subjects with a combination of MR sequences previously reported to be sensitive to nigral cell loss. Striatal regions of interest were defined on T1-weighted MRI coregistered to 18SF-dopa PET in all subjects. Results: Discriminant function analysis of the quantified MR nigral signal correctly classified 83% of the combined PD patient/control group; three of 10 PD cases were incorrectly classified as "normal" (Wilks' λ = 0.724, p > 0.05). Discriminant function analysis correctly classified 100% of PD patients and control subjects with 18SF-dopa PET based on mean caudate and putamen Ki values (Wilks' λ = 0.065, p < 0.001). Correlations between mean putamen Ki and rostral and caudal nigral MR signal changes and mean caudate Ki and caudal nigral MR signal changes were found (r = -0.76, -0.69, -0.80, p < 0.05). Conclusion: 18F-dopa PET is more reliable than inversion recovery MRI in discriminating patients with moderately severe PD from normal subjects. However, the structural changes detected within the substantia nigra of patients with PD found using inversion recovery MRI correlate with measures of striatal dopaminergic function using 18F-dopa PET.

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A comparison of ¹⁸F-dopa PET and inversion recovery MRI in the diagnosis of parkinson's disease

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