A comparison of the effects of raloxifene and conjugated equine estrogen on bone and lipids in healthy postmenopausal women

I R Reid; R Eastell; I Fogelman; J D Adachi; A Rosen; C Netelenbos; N B Watts; E Seeman; A V Ciaccia; M W Draper

doi:10.1001/archinte.164.8.871

A comparison of the effects of raloxifene and conjugated equine estrogen on bone and lipids in healthy postmenopausal women

I R Reid, R Eastell, I Fogelman, J D Adachi, A Rosen, C Netelenbos, N B Watts, E Seeman, A V Ciaccia, M W Draper

Cancer Imaging

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Abstract

Background: Although many studies have assessed the effects of estrogen and raloxifene hydrochloride on bone mineral density and serum lipid concentrations, there are few direct comparative data. Methods: Randomized placebo-controlled trial for 3 years, intention-to-treat analysis. Six hundred nineteen postmenopausal women with prior hysterectomy (mean age, 53.0 years) were studied in 38 centers in Europe, North America, Australasia, and South Africa. The), were randomized to 60 mg/d or 150 mg/d of raloxifene, 0.625 mg/d of conjugated equine estrogen (CEE), or placebo. Bone density of the lumbar spine and proximal femur, biochemical markers of bone turnover, and fasting serum lipid concentrations were assessed for 3 years. Results: Compared with baseline, bone density in the lumbar spine progressively declined by 2.0% in the placebo group (P

Original language	English
Pages (from-to)	871 - 879
Number of pages	9
Journal	Archives of Internal Medicine
Volume	164
Issue number	8
DOIs	https://doi.org/10.1001/archinte.164.8.871
Publication status	Published - 26 Apr 2004

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AU - Reid, I R

AU - Eastell, R

AU - Fogelman, I

AU - Adachi, J D

AU - Rosen, A

AU - Netelenbos, C

AU - Watts, N B

AU - Seeman, E

AU - Ciaccia, A V

AU - Draper, M W

PY - 2004/4/26

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A comparison of the effects of raloxifene and conjugated equine estrogen on bone and lipids in healthy postmenopausal women

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