A comprehensive review and model of putative prodromal features of bipolar affective disorder

O. D. Howes; S. Lim; G. Theologos; A. R. Yung; G. M. Goodwin; P. McGuire

doi:10.1017/S0033291710001790

A comprehensive review and model of putative prodromal features of bipolar affective disorder

O. D. Howes, S. Lim, G. Theologos, A. R. Yung, G. M. Goodwin, P. McGuire

Research output: Contribution to journal › Article › peer-review

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Abstract

Background. Identifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. This review addresses two key questions : Is there a bipolar prodrome? And, if there is, what are its characteristic features ? Method. A comprehensive search of databases (PubMed, Medline, EMBASE and PsycINFO) supplemented by hand searches was used to identify studies of symptoms preceding the onset of BD. Results. Fifty-nine studies were identified, of which 14 met inclusion criteria. Symptoms can predate the onset of BD by months to years and can be categorized as attenuated forms of BD symptoms, general symptoms common to a range of mental disorders, and personality traits, particularly cyclothymia. Two studies provided sufficient data to enable sensitivity and specificity to be calculated. Specificity of several of the features was high (>90%) but sensitivity was generally low (all

Original language	English
Pages (from-to)	1567 - 1577
Number of pages	11
Journal	Psychological Medicine
Volume	41
Issue number	8
DOIs	https://doi.org/10.1017/S0033291710001790
Publication status	Published - Aug 2011

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abstract = "Background. Identifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. This review addresses two key questions : Is there a bipolar prodrome? And, if there is, what are its characteristic features ? Method. A comprehensive search of databases (PubMed, Medline, EMBASE and PsycINFO) supplemented by hand searches was used to identify studies of symptoms preceding the onset of BD. Results. Fifty-nine studies were identified, of which 14 met inclusion criteria. Symptoms can predate the onset of BD by months to years and can be categorized as attenuated forms of BD symptoms, general symptoms common to a range of mental disorders, and personality traits, particularly cyclothymia. Two studies provided sufficient data to enable sensitivity and specificity to be calculated. Specificity of several of the features was high (>90%) but sensitivity was generally low (all ",

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AU - Howes, O. D.

AU - Lim, S.

AU - Theologos, G.

AU - Yung, A. R.

AU - Goodwin, G. M.

AU - McGuire, P.

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A comprehensive review and model of putative prodromal features of bipolar affective disorder

Abstract

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