A dedicated neonatal brain imaging system

Emer J Hughes; Tobias Winchman; Francesco Padormo; Rui Teixeira; Julia Wurie; Maryanne Sharma; Matthew Fox; Jana Hutter; Lucilio Cordero-Grande; Anthony N Price; Joanna Allsop; Jose Bueno-Conde; Nora Tusor; Tomoki Arichi; A D Edwards; Mary A Rutherford; Serena J Counsell; Joseph V Hajnal

doi:10.1002/mrm.26462

A dedicated neonatal brain imaging system

Emer J Hughes, Tobias Winchman, Francesco Padormo, Rui Teixeira, Julia Wurie, Maryanne Sharma, Matthew Fox, Jana Hutter, Lucilio Cordero-Grande, Anthony N Price, Joanna Allsop, Jose Bueno-Conde, Nora Tusor, Tomoki Arichi, A D Edwards, Mary A Rutherford, Serena J Counsell, Joseph V Hajnal

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Abstract

PURPOSE: The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.

METHODS: We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.

RESULTS: The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.

CONCLUSION: The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates.

Original language	English
Pages (from-to)	794-804
Journal	Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume	78
Issue number	2
Early online date	19 Sept 2016
DOIs	https://doi.org/10.1002/mrm.26462
Publication status	Published - Aug 2017

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A dedicated neonatal brain_HUGHES_Publishedonline19September2016_GOLD VoRFinal published version, 629 KBLicence: CC BY-NC-ND

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Hughes, E. J., Winchman, T., Padormo, F., Teixeira, R., Wurie, J., Sharma, M., Fox, M., Hutter, J., Cordero-Grande, L., Price, A. N., Allsop, J., Bueno-Conde, J., Tusor, N., Arichi, T., Edwards, A. D., Rutherford, M. A., Counsell, S. J., & Hajnal, J. V. (2017). A dedicated neonatal brain imaging system. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 78(2), 794-804. https://doi.org/10.1002/mrm.26462

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title = "A dedicated neonatal brain imaging system",

abstract = "PURPOSE: The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.METHODS: We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.RESULTS: The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.CONCLUSION: The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates.",

author = "Hughes, {Emer J} and Tobias Winchman and Francesco Padormo and Rui Teixeira and Julia Wurie and Maryanne Sharma and Matthew Fox and Jana Hutter and Lucilio Cordero-Grande and Price, {Anthony N} and Joanna Allsop and Jose Bueno-Conde and Nora Tusor and Tomoki Arichi and Edwards, {A D} and Rutherford, {Mary A} and Counsell, {Serena J} and Hajnal, {Joseph V}",

note = "{\textcopyright} 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.",

year = "2017",

month = aug,

doi = "10.1002/mrm.26462",

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Hughes, EJ, Winchman, T, Padormo, F , Teixeira, R, Wurie, J, Sharma, M, Fox, M, Hutter, J , Cordero-Grande, L , Price, AN, Allsop, J, Bueno-Conde, J, Tusor, N , Arichi, T , Edwards, AD , Rutherford, MA , Counsell, SJ & Hajnal, JV 2017, 'A dedicated neonatal brain imaging system', Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, vol. 78, no. 2, pp. 794-804. https://doi.org/10.1002/mrm.26462

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T1 - A dedicated neonatal brain imaging system

AU - Hughes, Emer J

AU - Winchman, Tobias

AU - Padormo, Francesco

AU - Teixeira, Rui

AU - Wurie, Julia

AU - Sharma, Maryanne

AU - Fox, Matthew

AU - Hutter, Jana

AU - Cordero-Grande, Lucilio

AU - Price, Anthony N

AU - Allsop, Joanna

AU - Bueno-Conde, Jose

AU - Tusor, Nora

AU - Arichi, Tomoki

AU - Edwards, A D

AU - Rutherford, Mary A

AU - Counsell, Serena J

AU - Hajnal, Joseph V

PY - 2017/8

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N2 - PURPOSE: The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.METHODS: We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.RESULTS: The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.CONCLUSION: The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates.

AB - PURPOSE: The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.METHODS: We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.RESULTS: The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.CONCLUSION: The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates.

U2 - 10.1002/mrm.26462

DO - 10.1002/mrm.26462

M3 - Article

C2 - 27643791

SN - 1522-2594

VL - 78

SP - 794

EP - 804

JO - Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine

JF - Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine

IS - 2

ER -

A dedicated neonatal brain imaging system

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