A family-based and case-control association study of the NOTCH4 gene and schizophrenia

J. B. Fan; J. X. Tang; N. F. Gu; G. Y. Feng; F. G. Zou; Y. L. Xing; J. G. Shi; S. M. Zhao; S. M. Zhu; L. P. Ji; W. W. Sun; Y. L. Zheng; W. Q. Liu; G. Breen; D. S. Clair; L. He

doi:10.1038/sj/mp/4000945

A family-based and case-control association study of the NOTCH4 gene and schizophrenia

J. B. Fan, J. X. Tang, N. F. Gu, G. Y. Feng, F. G. Zou, Y. L. Xing, J. G. Shi, S. M. Zhao, S. M. Zhu, L. P. Ji, W. W. Sun, Y. L. Zheng, W. Q. Liu, G. Breen, D. S. Clair, L. He

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Abstract

Recently a strong positive association between schizophrenia and Notch4 has been reported.(1) Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as >300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations.

Original language	English
Pages (from-to)	100-103
Number of pages	4
Journal	Molecular Psychiatry
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/sj/mp/4000945
Publication status	Published - 2002

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title = "A family-based and case-control association study of the NOTCH4 gene and schizophrenia",

abstract = "Recently a strong positive association between schizophrenia and Notch4 has been reported.(1) Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as >300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations.",

author = "Fan, {J. B.} and Tang, {J. X.} and Gu, {N. F.} and Feng, {G. Y.} and Zou, {F. G.} and Xing, {Y. L.} and Shi, {J. G.} and Zhao, {S. M.} and Zhu, {S. M.} and Ji, {L. P.} and Sun, {W. W.} and Zheng, {Y. L.} and Liu, {W. Q.} and G. Breen and Clair, {D. S.} and L. He",

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doi = "10.1038/sj/mp/4000945",

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T1 - A family-based and case-control association study of the NOTCH4 gene and schizophrenia

AU - Fan, J. B.

AU - Tang, J. X.

AU - Gu, N. F.

AU - Feng, G. Y.

AU - Zou, F. G.

AU - Xing, Y. L.

AU - Shi, J. G.

AU - Zhao, S. M.

AU - Zhu, S. M.

AU - Ji, L. P.

AU - Sun, W. W.

AU - Zheng, Y. L.

AU - Liu, W. Q.

AU - Breen, G.

AU - Clair, D. S.

AU - He, L.

N1 - Times Cited: 41

PY - 2002

Y1 - 2002

N2 - Recently a strong positive association between schizophrenia and Notch4 has been reported.(1) Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as >300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations.

AB - Recently a strong positive association between schizophrenia and Notch4 has been reported.(1) Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as >300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations.

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DO - 10.1038/sj/mp/4000945

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EP - 103

JO - Molecular Psychiatry

JF - Molecular Psychiatry

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A family-based and case-control association study of the NOTCH4 gene and schizophrenia

Abstract

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