A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

Hanneke J. M. Kerkhof; Rik J. Lories; Ingrid Meulenbelt; Ingileif Jonsdottir; Ana M. Valdes; Pascal Arp; Thorvaldur Ingvarsson; Mila Jhamai; Helgi Jonsson; Lisette Stolk; Gudmar Thorleifsson; Guangju Zhai; Feng Zhang; Yanyan Zhu; Ruud van der Breggen; Andrew Carr; Michael Doherty; Sally Doherty; David T. Felson; Antonio Gonzalez; Bjarni V. Halldorsson; Deborah J. Hart; Valdimar B. Hauksson; Albert Hofman; John P. A. Ioannidis; Margreet Kloppenburg; Nancy E. Lane; John Loughlin; Frank P. Luyten; Michael C. Nevitt; Neeta Parimi; Huibert A. P. Pols; Fernando Rivadeneira; Eline P. Slagboom; Unnur Styrkarsdottir; Aspasia Tsezou; Tom van de Putte; Joseph Zmuda; Tim D. Spector; Kari Stefansson; Andre G. Uitterlinden; Joyce B. J. van Meurs

doi:10.1002/art.27184

A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

Hanneke J. M. Kerkhof, Rik J. Lories, Ingrid Meulenbelt, Ingileif Jonsdottir, Ana M. Valdes, Pascal Arp, Thorvaldur Ingvarsson, Mila Jhamai, Helgi Jonsson, Lisette Stolk, Gudmar Thorleifsson, Guangju Zhai, Feng Zhang, Yanyan Zhu, Ruud van der Breggen, Andrew Carr, Michael Doherty, Sally Doherty, David T. Felson, Antonio GonzalezBjarni V. Halldorsson, Deborah J. Hart, Valdimar B. Hauksson, Albert Hofman, John P. A. Ioannidis, Margreet Kloppenburg, Nancy E. Lane, John Loughlin, Frank P. Luyten, Michael C. Nevitt, Neeta Parimi, Huibert A. P. Pols, Fernando Rivadeneira, Eline P. Slagboom, Unnur Styrkarsdottir, Aspasia Tsezou, Tom van de Putte, Joseph Zmuda, Tim D. Spector, Kari Stefansson, Andre G. Uitterlinden, Joyce B. J. van Meurs

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Abstract

Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and similar to 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values

Original language	English
Pages (from-to)	499 - 510
Number of pages	12
Journal	Arthritis & Rheumatism
Volume	62
Issue number	2
DOIs	https://doi.org/10.1002/art.27184
Publication status	Published - Feb 2010

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Kerkhof, H. J. M., Lories, R. J., Meulenbelt, I., Jonsdottir, I., Valdes, A. M., Arp, P., Ingvarsson, T., Jhamai, M., Jonsson, H., Stolk, L., Thorleifsson, G., Zhai, G., Zhang, F., Zhu, Y., van der Breggen, R., Carr, A., Doherty, M., Doherty, S., Felson, D. T., ... van Meurs, J. B. J. (2010). A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22. Arthritis & Rheumatism, 62(2), 499 - 510. https://doi.org/10.1002/art.27184

@article{6568e7d0f7014a6b8fc6dbb46a7cd93b,

title = "A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22",

abstract = "Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and similar to 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values ",

author = "Kerkhof, {Hanneke J. M.} and Lories, {Rik J.} and Ingrid Meulenbelt and Ingileif Jonsdottir and Valdes, {Ana M.} and Pascal Arp and Thorvaldur Ingvarsson and Mila Jhamai and Helgi Jonsson and Lisette Stolk and Gudmar Thorleifsson and Guangju Zhai and Feng Zhang and Yanyan Zhu and {van der Breggen}, Ruud and Andrew Carr and Michael Doherty and Sally Doherty and Felson, {David T.} and Antonio Gonzalez and Halldorsson, {Bjarni V.} and Hart, {Deborah J.} and Hauksson, {Valdimar B.} and Albert Hofman and Ioannidis, {John P. A.} and Margreet Kloppenburg and Lane, {Nancy E.} and John Loughlin and Luyten, {Frank P.} and Nevitt, {Michael C.} and Neeta Parimi and Pols, {Huibert A. P.} and Fernando Rivadeneira and Slagboom, {Eline P.} and Unnur Styrkarsdottir and Aspasia Tsezou and {van de Putte}, Tom and Joseph Zmuda and Spector, {Tim D.} and Kari Stefansson and Uitterlinden, {Andre G.} and {van Meurs}, {Joyce B. J.}",

year = "2010",

month = feb,

doi = "10.1002/art.27184",

language = "English",

volume = "62",

pages = "499 -- 510",

journal = "Arthritis & Rheumatism",

issn = "1529-0131",

publisher = "John Wiley and Sons Inc.",

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Kerkhof, HJM, Lories, RJ, Meulenbelt, I, Jonsdottir, I, Valdes, AM, Arp, P, Ingvarsson, T, Jhamai, M, Jonsson, H, Stolk, L, Thorleifsson, G, Zhai, G , Zhang, F, Zhu, Y, van der Breggen, R, Carr, A, Doherty, M, Doherty, S, Felson, DT, Gonzalez, A, Halldorsson, BV, Hart, DJ, Hauksson, VB, Hofman, A, Ioannidis, JPA, Kloppenburg, M, Lane, NE, Loughlin, J, Luyten, FP, Nevitt, MC, Parimi, N, Pols, HAP, Rivadeneira, F, Slagboom, EP, Styrkarsdottir, U, Tsezou, A, van de Putte, T, Zmuda, J, Spector, TD, Stefansson, K, Uitterlinden, AG & van Meurs, JBJ 2010, 'A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22', Arthritis & Rheumatism, vol. 62, no. 2, pp. 499 - 510. https://doi.org/10.1002/art.27184

TY - JOUR

T1 - A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

AU - Kerkhof, Hanneke J. M.

AU - Lories, Rik J.

AU - Meulenbelt, Ingrid

AU - Jonsdottir, Ingileif

AU - Valdes, Ana M.

AU - Arp, Pascal

AU - Ingvarsson, Thorvaldur

AU - Jhamai, Mila

AU - Jonsson, Helgi

AU - Stolk, Lisette

AU - Thorleifsson, Gudmar

AU - Zhai, Guangju

AU - Zhang, Feng

AU - Zhu, Yanyan

AU - van der Breggen, Ruud

AU - Carr, Andrew

AU - Doherty, Michael

AU - Doherty, Sally

AU - Felson, David T.

AU - Gonzalez, Antonio

AU - Halldorsson, Bjarni V.

AU - Hart, Deborah J.

AU - Hauksson, Valdimar B.

AU - Hofman, Albert

AU - Ioannidis, John P. A.

AU - Kloppenburg, Margreet

AU - Lane, Nancy E.

AU - Loughlin, John

AU - Luyten, Frank P.

AU - Nevitt, Michael C.

AU - Parimi, Neeta

AU - Pols, Huibert A. P.

AU - Rivadeneira, Fernando

AU - Slagboom, Eline P.

AU - Styrkarsdottir, Unnur

AU - Tsezou, Aspasia

AU - van de Putte, Tom

AU - Zmuda, Joseph

AU - Spector, Tim D.

AU - Stefansson, Kari

AU - Uitterlinden, Andre G.

AU - van Meurs, Joyce B. J.

PY - 2010/2

Y1 - 2010/2

N2 - Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and similar to 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values

AB - Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and similar to 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values

U2 - 10.1002/art.27184

DO - 10.1002/art.27184

M3 - Article

SN - 1529-0131

VL - 62

SP - 499

EP - 510

JO - Arthritis & Rheumatism

JF - Arthritis & Rheumatism

IS - 2

ER -

A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

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