A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition

Bernd B. Zeisig; Chi Wai Eric So

doi:10.1016/j.stem.2014.09.006

A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition

Bernd B. Zeisig, Chi Wai Eric So^*

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › peer-review

2 Citations (Scopus)

Abstract

SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.

Original language	English
Pages (from-to)	395-397
Number of pages	3
Journal	Cell Stem Cell
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2014.09.006
Publication status	Published - 2 Oct 2014

Keywords

ACUTE MYELOID-LEUKEMIA
CANCER
ACTIVATION
EVOLUTION
P53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stem.2014.09.006

Cite this

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title = "A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition",

abstract = "SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.",

keywords = "ACUTE MYELOID-LEUKEMIA, CANCER, ACTIVATION, EVOLUTION, P53",

author = "Zeisig, {Bernd B.} and So, {Chi Wai Eric}",

year = "2014",

month = oct,

day = "2",

doi = "10.1016/j.stem.2014.09.006",

language = "English",

volume = "15",

pages = "395--397",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "4",

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TY - JOUR

T1 - A Knockout Combo

T2 - Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition

AU - Zeisig, Bernd B.

AU - So, Chi Wai Eric

PY - 2014/10/2

Y1 - 2014/10/2

N2 - SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.

AB - SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.

KW - ACUTE MYELOID-LEUKEMIA

KW - CANCER

KW - ACTIVATION

KW - EVOLUTION

KW - P53

U2 - 10.1016/j.stem.2014.09.006

DO - 10.1016/j.stem.2014.09.006

M3 - Editorial

SN - 1934-5909

VL - 15

SP - 395

EP - 397

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

A Knockout Combo: Eradicating AML Stem Cells with TKI plus SIRT1 Inhibition

Abstract

Keywords

UN SDGs

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