A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Christian Schulz; Elisa Gomez Perdiguero; Laurent Chorro; Heather Szabo Rogers; N Cagnard; K Kierdorf; M Prinz; B Wu; SE Jacobsen; JW Pollard; J Frampton; Karen Liu; Frederic Geissmann

doi:10.1126/science.1219179

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, Heather Szabo Rogers, N Cagnard, K Kierdorf, M Prinz, B Wu, SE Jacobsen, JW Pollard, J Frampton, Karen Liu, Frederic Geissmann

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1998 Citations (Scopus)

Abstract

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia-cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

Original language	English
Pages (from-to)	86 - 90
Number of pages	5
Journal	Science
Volume	336
Issue number	6077
DOIs	https://doi.org/10.1126/science.1219179
Publication status	Published - 6 Apr 2012

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10.1126/science.1219179

http://www.sciencemag.org/content/336/6077/86.full

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title = "A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells",

abstract = "Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia-cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.",

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T1 - A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

AU - Schulz, Christian

AU - Gomez Perdiguero, Elisa

AU - Chorro, Laurent

AU - Szabo Rogers, Heather

AU - Cagnard, N

AU - Kierdorf, K

AU - Prinz, M

AU - Wu, B

AU - Jacobsen, SE

AU - Pollard, JW

AU - Frampton, J

AU - Liu, Karen

AU - Geissmann, Frederic

PY - 2012/4/6

Y1 - 2012/4/6

N2 - Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia-cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

AB - Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia-cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

U2 - 10.1126/science.1219179

DO - 10.1126/science.1219179

M3 - Article

SN - 1095-9203

VL - 336

SP - 86

EP - 90

JO - Science

JF - Science

IS - 6077

ER -

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Abstract

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