A lineage of myeloid cells independent of Myb and hematopoietic stem cells

Christian Schulz; Elisa Gomez Perdiguero; Laurent Chorro; Heather Szabo-Rogers; Nicolas Cagnard; Katrin Kierdorf; Marco Prinz; Bishan Wu; Sten Eirik W Jacobsen; Jeffrey W Pollard; Jon Frampton; Karen J Liu; Frederic Geissmann

doi:10.1126/science.1219179

A lineage of myeloid cells independent of Myb and hematopoietic stem cells

Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, Heather Szabo-Rogers, Nicolas Cagnard, Katrin Kierdorf, Marco Prinz, Bishan Wu, Sten Eirik W Jacobsen, Jeffrey W Pollard, Jon Frampton, Karen J Liu, Frederic Geissmann

Research output: Contribution to journal › Article › peer-review

1966 Citations (Scopus)

Abstract

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

Original language	English
Pages (from-to)	86-90
Number of pages	5
Journal	Science
Volume	336
Issue number	6077
DOIs	https://doi.org/10.1126/science.1219179
Publication status	Published - 6 Apr 2012

Keywords

Macrophages
Proto-Oncogene Proteins c-myb
Animals
Dendritic Cells
Myelopoiesis
Cell Lineage
Genes, myb
Hematopoietic Stem Cells
Chick Embryo
Kupffer Cells
Mice
Yolk Sac
Microglia
Cell Proliferation
Gene Deletion
Proto-Oncogene Proteins
Langerhans Cells
Liver
Myeloid Cells
Trans-Activators
Embryo, Mammalian
Gene Expression Regulation, Developmental

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10.1126/science.1219179

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title = "A lineage of myeloid cells independent of Myb and hematopoietic stem cells",

abstract = "Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.",

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author = "Christian Schulz and {Gomez Perdiguero}, Elisa and Laurent Chorro and Heather Szabo-Rogers and Nicolas Cagnard and Katrin Kierdorf and Marco Prinz and Bishan Wu and Jacobsen, {Sten Eirik W} and Pollard, {Jeffrey W} and Jon Frampton and Liu, {Karen J} and Frederic Geissmann",

year = "2012",

month = apr,

day = "6",

doi = "10.1126/science.1219179",

language = "English",

volume = "336",

pages = "86--90",

journal = "Science",

issn = "0036-8075",

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TY - JOUR

T1 - A lineage of myeloid cells independent of Myb and hematopoietic stem cells

AU - Schulz, Christian

AU - Gomez Perdiguero, Elisa

AU - Chorro, Laurent

AU - Szabo-Rogers, Heather

AU - Cagnard, Nicolas

AU - Kierdorf, Katrin

AU - Prinz, Marco

AU - Wu, Bishan

AU - Jacobsen, Sten Eirik W

AU - Pollard, Jeffrey W

AU - Frampton, Jon

AU - Liu, Karen J

AU - Geissmann, Frederic

PY - 2012/4/6

Y1 - 2012/4/6

N2 - Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

AB - Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

KW - Macrophages

KW - Proto-Oncogene Proteins c-myb

KW - Animals

KW - Dendritic Cells

KW - Myelopoiesis

KW - Cell Lineage

KW - Genes, myb

KW - Hematopoietic Stem Cells

KW - Chick Embryo

KW - Kupffer Cells

KW - Mice

KW - Yolk Sac

KW - Microglia

KW - Cell Proliferation

KW - Gene Deletion

KW - Proto-Oncogene Proteins

KW - Langerhans Cells

KW - Liver

KW - Myeloid Cells

KW - Trans-Activators

KW - Embryo, Mammalian

KW - Gene Expression Regulation, Developmental

U2 - 10.1126/science.1219179

DO - 10.1126/science.1219179

M3 - Article

C2 - 22442384

SN - 0036-8075

VL - 336

SP - 86

EP - 90

JO - Science

JF - Science

IS - 6077

ER -

A lineage of myeloid cells independent of Myb and hematopoietic stem cells

Abstract

Keywords

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