A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder

Edward Barker; Esther Walton; Charlotte Cecil; Sara Jaffee; Richard Rowe; Thomas G.  O'Connor; Barbara Maughan; Argyris Stringaris; Alan Meehan; Wendy McArdle; Caroline Relton; Tom R. Gaunt

doi:10.1111/cdev.12957

A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder

Edward Barker, Esther Walton, Charlotte Cecil, Sara Jaffee, Richard Rowe, Thomas G. O'Connor, Barbara Maughan, Argyris Stringaris, Alan Meehan, Wendy McArdle, Caroline Relton, Tom R. Gaunt

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Abstract

In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7 to 13) of oppositional defiant disorder (ODD), and the ODD sub-dimensions of Irritable and Headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and Headstrong but not for Irritable. Overlap analysis indicated biological correlates between ODD, Headstrong and ADHD. DNA methylation in ODD and Headstrong was partially genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (Headstrong) and cigarette smoking (ODD and Headstrong).

Original language	English
Pages (from-to)	1839-1855
Journal	Child Development
Volume	89
Issue number	5
Early online date	20 Sept 2017
DOIs	https://doi.org/10.1111/cdev.12957
Publication status	Published - 7 Sept 2018

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A methylome-wide association_BARKER_Accepted7June2017_GOLD AAM (CC BY)Accepted author manuscript, 743 KBLicence: CC BY
A methylome-wide association_BARKER_Publishedonline20September2017_GOLD VoR (CC BY)Final published version, 478 KBLicence: CC BY

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Barker, E., Walton, E., Cecil, C., Jaffee, S., Rowe, R., O'Connor, T. G., Maughan, B., Stringaris, A., Meehan, A., McArdle, W., Relton, C., & Gaunt, T. R. (2018). A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder. Child Development, 89(5), 1839-1855. https://doi.org/10.1111/cdev.12957

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title = "A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder",

abstract = "In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7 to 13) of oppositional defiant disorder (ODD), and the ODD sub-dimensions of Irritable and Headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and Headstrong but not for Irritable. Overlap analysis indicated biological correlates between ODD, Headstrong and ADHD. DNA methylation in ODD and Headstrong was partially genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (Headstrong) and cigarette smoking (ODD and Headstrong). ",

author = "Edward Barker and Esther Walton and Charlotte Cecil and Sara Jaffee and Richard Rowe and O'Connor, {Thomas G.} and Barbara Maughan and Argyris Stringaris and Alan Meehan and Wendy McArdle and Caroline Relton and Gaunt, {Tom R.}",

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Barker, E , Walton, E , Cecil, C , Jaffee, S, Rowe, R, O'Connor, TG, Maughan, B , Stringaris, A , Meehan, A, McArdle, W, Relton, C & Gaunt, TR 2018, 'A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder', Child Development, vol. 89, no. 5, pp. 1839-1855. https://doi.org/10.1111/cdev.12957

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T1 - A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder

AU - Barker, Edward

AU - Walton, Esther

AU - Cecil, Charlotte

AU - Jaffee, Sara

AU - Rowe, Richard

AU - O'Connor, Thomas G.

AU - Maughan, Barbara

AU - Stringaris, Argyris

AU - Meehan, Alan

AU - McArdle, Wendy

AU - Relton, Caroline

AU - Gaunt, Tom R.

PY - 2018/9/7

Y1 - 2018/9/7

N2 - In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7 to 13) of oppositional defiant disorder (ODD), and the ODD sub-dimensions of Irritable and Headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and Headstrong but not for Irritable. Overlap analysis indicated biological correlates between ODD, Headstrong and ADHD. DNA methylation in ODD and Headstrong was partially genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (Headstrong) and cigarette smoking (ODD and Headstrong).

AB - In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7 to 13) of oppositional defiant disorder (ODD), and the ODD sub-dimensions of Irritable and Headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and Headstrong but not for Irritable. Overlap analysis indicated biological correlates between ODD, Headstrong and ADHD. DNA methylation in ODD and Headstrong was partially genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (Headstrong) and cigarette smoking (ODD and Headstrong).

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DO - 10.1111/cdev.12957

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SP - 1839

EP - 1855

JO - Child Development

JF - Child Development

IS - 5

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A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder

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