A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity

Jonathan Powell, Sylvaine Bruggraber, Nuno Faria, Lynsey K. Poots, Nicole Hondow, Timothy J. Pennycook, Gladys Latunde-Dada, Robert Simpson, Andy P. Brown, Dora I.A. Pereira

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)
195 Downloads (Pure)

Abstract

The 2-5nm Fe(III) oxo-hydroxide core of ferritin is less ordered and readily bioavailable compared to its pure synthetic analogue, ferrihydrite. We report the facile synthesis of tartrate-modified, nano-disperse ferrihydrite of small primary particle size, but with enlarged or strained lattice structure (~2.7Å for the main Bragg peak versus 2.6Å for synthetic ferrihydrite). Analysis indicated that co-precipitation conditions can be achieved for tartrate inclusion into the developing ferrihydrite particles, retarding both growth and crystallization and favoring stabilization of the cross-linked polymeric structure. In murine models, gastrointestinal uptake was independent of luminal Fe(III) reduction to Fe(II) and, yet, absorption was equivalent to that of ferrous sulphate, efficiently correcting the induced anemia. This process may model dietary Fe(III) absorption and potentially provide a side effect-free form of cheap supplemental iron.
Original languageEnglish
Pages (from-to)1529-1538
JournalNanomedicine : nanotechnology, biology, and medicine
Volume10
Issue number7
Early online date4 Jan 2014
DOIs
Publication statusPublished - 31 Oct 2014

Keywords

  • Bioavailability, Ferrihydrite, Iron deficiency anemia, Iron oxide, Oral iron

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