TY - JOUR
T1 - A practical guide to thiopurine prescribing and monitoring in IBD
AU - Warner, Ben
AU - Johnston, Emma
AU - Arenas-HernandeZ, Monica
AU - Marinaki, Anthony
AU - Irving, Peter
AU - Sanderson, Jeremy
PY - 2018
Y1 - 2018
N2 - Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.
AB - Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.
UR - http://www.scopus.com/inward/record.url?scp=85041739799&partnerID=8YFLogxK
U2 - 10.1136/flgastro-2016-100738
DO - 10.1136/flgastro-2016-100738
M3 - Review article
AN - SCOPUS:85041739799
SN - 2041-4137
VL - 9
SP - 10
EP - 15
JO - Frontline Gastroenterology
JF - Frontline Gastroenterology
IS - 1
ER -