A review of feto-placental vasculature flow modelling

Joanna Chappell; Rosalind Aughwane; Alys R. Clark; Sebastien Ourselin; Anna L. David; Andrew Melbourne

doi:10.1016/j.placenta.2023.08.068

A review of feto-placental vasculature flow modelling

Joanna Chappell^*, Rosalind Aughwane, Alys R. Clark, Sebastien Ourselin, Anna L. David, Andrew Melbourne

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The placenta provides the vital nutrients and removal of waste products required for fetal growth and development. Understanding and quantifying the differences in structure and function between a normally functioning placenta compared to an abnormal placenta is vital to provide insights into the aetiology and treatment options for fetal growth restriction and other placental disorders. Computational modelling of blood flow in the placenta allows a new understanding of the placental circulation to be obtained. This structured review discusses multiple recent methods for placental vascular model development including analysis of the appearance of the placental vasculature and how placental haemodynamics may be simulated at multiple length scales.

Original language	English
Pages (from-to)	56-63
Number of pages	8
Journal	Placenta
Volume	142
DOIs	https://doi.org/10.1016/j.placenta.2023.08.068
Publication status	Published - Oct 2023

Keywords

Computational modelling
Placenta
Placenta flow modelling
Placental haemodynamics

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10.1016/j.placenta.2023.08.068

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title = "A review of feto-placental vasculature flow modelling",

abstract = "The placenta provides the vital nutrients and removal of waste products required for fetal growth and development. Understanding and quantifying the differences in structure and function between a normally functioning placenta compared to an abnormal placenta is vital to provide insights into the aetiology and treatment options for fetal growth restriction and other placental disorders. Computational modelling of blood flow in the placenta allows a new understanding of the placental circulation to be obtained. This structured review discusses multiple recent methods for placental vascular model development including analysis of the appearance of the placental vasculature and how placental haemodynamics may be simulated at multiple length scales.",

keywords = "Computational modelling, Placenta, Placenta flow modelling, Placental haemodynamics",

author = "Joanna Chappell and Rosalind Aughwane and Clark, {Alys R.} and Sebastien Ourselin and David, {Anna L.} and Andrew Melbourne",

note = "Funding Information: This research was funded by the Wellcome Trust ( 210182/Z/18/Z ), EPSRC ( NS/A000027/1 ) and MRC MR/X010007/1 . Publisher Copyright: {\textcopyright} 2023",

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T1 - A review of feto-placental vasculature flow modelling

AU - Chappell, Joanna

AU - Aughwane, Rosalind

AU - Clark, Alys R.

AU - Ourselin, Sebastien

AU - David, Anna L.

AU - Melbourne, Andrew

PY - 2023/10

Y1 - 2023/10

N2 - The placenta provides the vital nutrients and removal of waste products required for fetal growth and development. Understanding and quantifying the differences in structure and function between a normally functioning placenta compared to an abnormal placenta is vital to provide insights into the aetiology and treatment options for fetal growth restriction and other placental disorders. Computational modelling of blood flow in the placenta allows a new understanding of the placental circulation to be obtained. This structured review discusses multiple recent methods for placental vascular model development including analysis of the appearance of the placental vasculature and how placental haemodynamics may be simulated at multiple length scales.

AB - The placenta provides the vital nutrients and removal of waste products required for fetal growth and development. Understanding and quantifying the differences in structure and function between a normally functioning placenta compared to an abnormal placenta is vital to provide insights into the aetiology and treatment options for fetal growth restriction and other placental disorders. Computational modelling of blood flow in the placenta allows a new understanding of the placental circulation to be obtained. This structured review discusses multiple recent methods for placental vascular model development including analysis of the appearance of the placental vasculature and how placental haemodynamics may be simulated at multiple length scales.

KW - Computational modelling

KW - Placenta

KW - Placenta flow modelling

KW - Placental haemodynamics

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DO - 10.1016/j.placenta.2023.08.068

M3 - Review article

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SN - 0143-4004

VL - 142

SP - 56

EP - 63

JO - Placenta

JF - Placenta

ER -

A review of feto-placental vasculature flow modelling

Abstract

Keywords

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