TY - JOUR
T1 - A signature pattern of cortical atrophy in dementia with Lewy bodies
T2 - a study on 333 patients from The European DLB Consortium
AU - Alzheimer’s Disease Neuroimaging Initiative
AU - Aarsland, Dag
PY - 2018/11/12
Y1 - 2018/11/12
N2 - BACKGROUND: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB).
METHODS: In this multicentre study we included a total of 333 DLB patients, 352 Alzheimer’s disease (AD) patients, and 233 normal controls and used medial temporal lobe atrophy (MTA), posterior atrophy (PA), and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns.
RESULTS: DLB had higher scores on all the three atrophy scales as compared to NC, but had less MTA than AD (all p-values <0.001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The MRI measures showed 65% ability to discriminate between DLB and AD, and marginally contributed to the discrimination over and above the core clinical features.
CONCLUSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
AB - BACKGROUND: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB).
METHODS: In this multicentre study we included a total of 333 DLB patients, 352 Alzheimer’s disease (AD) patients, and 233 normal controls and used medial temporal lobe atrophy (MTA), posterior atrophy (PA), and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns.
RESULTS: DLB had higher scores on all the three atrophy scales as compared to NC, but had less MTA than AD (all p-values <0.001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The MRI measures showed 65% ability to discriminate between DLB and AD, and marginally contributed to the discrimination over and above the core clinical features.
CONCLUSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
U2 - 10.1016/j.jalz.2018.09.011
DO - 10.1016/j.jalz.2018.09.011
M3 - Article
SN - 1552-5279
JO - Alzheimer's & dementia : the journal of the Alzheimer's Association
JF - Alzheimer's & dementia : the journal of the Alzheimer's Association
ER -