A systematic review of in vitro cytokine production in eating disorders

Bethan Dalton; Victoria Whitmore; Olivia Patsalos; Mohammad A A  Ibrahim; Ulrike Schmidt; Hubertus Himmerich

doi:10.1016/j.mce.2018.10.006

A systematic review of in vitro cytokine production in eating disorders

Bethan Dalton, Victoria Whitmore, Olivia Patsalos, Mohammad A A Ibrahim, Ulrike Schmidt, Hubertus Himmerich

a Faculty of Life Sciences and Medicine , King's College London , London , UK.

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Abstract

Background: Eating disorders (EDs) have been associated with alterations in cytokine concentrations and production. This review examines whether in vitro cytokine production (i) is altered in people with EDs compared to healthy participants; and (ii) changes in response to treatment?

Methods: Using PRISMA guidelines, we systematically reviewed articles reporting group comparisons or longitudinal assessments of spontaneous and/or stimulated cytokine production in vitro in EDs.

Results: Twelve studies were included. Cross-sectional results were mixed in anorexia nervosa (AN). Only one study measured cytokine production in bulimia nervosa. Two longitudinal studies showed that daily yoghurt consumption increases phytohemagglutinin-stimulated interferon-γ production in AN.

Conclusion: The mixed results could be accounted for by variations in experimental design. Our findings suggest that cytokine production could possibly be modulated through dietary interventions. However, due to the methodological heterogeneity and shortcomings of the included studies, it seems unreasonable to draw further conclusions.

Original language	English
Article number	110308
Journal	Molecular and Cellular Endocrinology
Early online date	6 Oct 2018
DOIs	https://doi.org/10.1016/j.mce.2018.10.006
Publication status	Published - 1 Nov 2019

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A systematic review of_DALTON_Firstonline6October2018_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 422 KBLicence: CC BY-NC-ND

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title = "A systematic review of in vitro cytokine production in eating disorders",

abstract = "Background: Eating disorders (EDs) have been associated with alterations in cytokine concentrations and production. This review examines whether in vitro cytokine production (i) is altered in people with EDs compared to healthy participants; and (ii) changes in response to treatment?Methods: Using PRISMA guidelines, we systematically reviewed articles reporting group comparisons or longitudinal assessments of spontaneous and/or stimulated cytokine production in vitro in EDs. Results: Twelve studies were included. Cross-sectional results were mixed in anorexia nervosa (AN). Only one study measured cytokine production in bulimia nervosa. Two longitudinal studies showed that daily yoghurt consumption increases phytohemagglutinin-stimulated interferon-γ production in AN.Conclusion: The mixed results could be accounted for by variations in experimental design. Our findings suggest that cytokine production could possibly be modulated through dietary interventions. However, due to the methodological heterogeneity and shortcomings of the included studies, it seems unreasonable to draw further conclusions. ",

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T1 - A systematic review of in vitro cytokine production in eating disorders

AU - Dalton, Bethan

AU - Whitmore, Victoria

AU - Patsalos, Olivia

AU - Ibrahim, Mohammad A A

AU - Schmidt, Ulrike

AU - Himmerich, Hubertus

PY - 2019/11/1

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N2 - Background: Eating disorders (EDs) have been associated with alterations in cytokine concentrations and production. This review examines whether in vitro cytokine production (i) is altered in people with EDs compared to healthy participants; and (ii) changes in response to treatment?Methods: Using PRISMA guidelines, we systematically reviewed articles reporting group comparisons or longitudinal assessments of spontaneous and/or stimulated cytokine production in vitro in EDs. Results: Twelve studies were included. Cross-sectional results were mixed in anorexia nervosa (AN). Only one study measured cytokine production in bulimia nervosa. Two longitudinal studies showed that daily yoghurt consumption increases phytohemagglutinin-stimulated interferon-γ production in AN.Conclusion: The mixed results could be accounted for by variations in experimental design. Our findings suggest that cytokine production could possibly be modulated through dietary interventions. However, due to the methodological heterogeneity and shortcomings of the included studies, it seems unreasonable to draw further conclusions.

AB - Background: Eating disorders (EDs) have been associated with alterations in cytokine concentrations and production. This review examines whether in vitro cytokine production (i) is altered in people with EDs compared to healthy participants; and (ii) changes in response to treatment?Methods: Using PRISMA guidelines, we systematically reviewed articles reporting group comparisons or longitudinal assessments of spontaneous and/or stimulated cytokine production in vitro in EDs. Results: Twelve studies were included. Cross-sectional results were mixed in anorexia nervosa (AN). Only one study measured cytokine production in bulimia nervosa. Two longitudinal studies showed that daily yoghurt consumption increases phytohemagglutinin-stimulated interferon-γ production in AN.Conclusion: The mixed results could be accounted for by variations in experimental design. Our findings suggest that cytokine production could possibly be modulated through dietary interventions. However, due to the methodological heterogeneity and shortcomings of the included studies, it seems unreasonable to draw further conclusions.

U2 - 10.1016/j.mce.2018.10.006

DO - 10.1016/j.mce.2018.10.006

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A systematic review of in vitro cytokine production in eating disorders

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