Abstract
OBJECTIVE-To assess the potential association between A1C variability (A1C-SD) and microalbuminuria in young people with type 1 diabetes.
RESEARCH DESIGN AND METHODS-Serially collected samples for A1C measurement were available for 1,232 subjects with childhood-onset type 1 diabetes recruited to the Oxford Regional Prospective Study and the Nephropathy Family Study.
RESULTS-The median (range) number of A1C assessments was 4(2-16). Mean intrapersonal A1C was 9.5% and A1C-SD was 0.91. Mean A1C and A1C-SD values were higher in subjects with microalbuminuria (a = 227) than in those with normoalbuminuria (10.3 vs. 9.4%; 1 12 vs. 0.86, P <0.001). In a Cox regression model, A1C-SD was independently associated with microalbuminuria (hazard ratio 1.31 [95% CI 1.01-1.35]).
CONCLUSIONS-In the current study, A1C variability was an independent variable that added to the effect of A1C on the risk for microalbuminuria in youth with type 1 diabetes, a population highly vulnerable to vascular complications.
Original language | English |
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Pages (from-to) | 1011 - 1013 |
Number of pages | 3 |
Journal | Diabetes Care |
Volume | 34 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2011 |