Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression

T Nakahara; K Hashimoto; M Hirano; M Koll; C R Martin; V R Preedy

doi:10.1152/ajpendo.00019.2003

Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression

T Nakahara, K Hashimoto, M Hirano, M Koll, C R Martin, V R Preedy

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Skeletal muscle atrophy is a common feature in alcoholism that affects up to two-thirds of alcohol misusers, and women appear to be particularly susceptible. There is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle. However, the mechanisms responsible for the myopathy remain elusive, and some studies suggest that acetaldehyde, rather than alcohol, is the principal pathogenic perturbant. Previous reports on rats dosed acutely with ethanol (

Original language	English
Pages (from-to)	E1273 - E1281
Journal	AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM
Volume	285
Issue number	6
DOIs	https://doi.org/10.1152/ajpendo.00019.2003
Publication status	Published - Dec 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1152/ajpendo.00019.2003

Cite this

@article{d7696a5edd114630959677b8af8b8206,

title = "Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression",

abstract = "Skeletal muscle atrophy is a common feature in alcoholism that affects up to two-thirds of alcohol misusers, and women appear to be particularly susceptible. There is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle. However, the mechanisms responsible for the myopathy remain elusive, and some studies suggest that acetaldehyde, rather than alcohol, is the principal pathogenic perturbant. Previous reports on rats dosed acutely with ethanol (",

author = "T Nakahara and K Hashimoto and M Hirano and M Koll and Martin, {C R} and Preedy, {V R}",

year = "2003",

month = dec,

doi = "10.1152/ajpendo.00019.2003",

language = "English",

volume = "285",

pages = "E1273 -- E1281",

journal = "AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM",

publisher = "American Physiological Society",

number = "6",

}

TY - JOUR

T1 - Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression

AU - Nakahara, T

AU - Hashimoto, K

AU - Hirano, M

AU - Koll, M

AU - Martin, C R

AU - Preedy, V R

PY - 2003/12

Y1 - 2003/12

N2 - Skeletal muscle atrophy is a common feature in alcoholism that affects up to two-thirds of alcohol misusers, and women appear to be particularly susceptible. There is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle. However, the mechanisms responsible for the myopathy remain elusive, and some studies suggest that acetaldehyde, rather than alcohol, is the principal pathogenic perturbant. Previous reports on rats dosed acutely with ethanol (

AB - Skeletal muscle atrophy is a common feature in alcoholism that affects up to two-thirds of alcohol misusers, and women appear to be particularly susceptible. There is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle. However, the mechanisms responsible for the myopathy remain elusive, and some studies suggest that acetaldehyde, rather than alcohol, is the principal pathogenic perturbant. Previous reports on rats dosed acutely with ethanol (

UR - http://www.scopus.com/inward/record.url?scp=0345327570&partnerID=8YFLogxK

U2 - 10.1152/ajpendo.00019.2003

DO - 10.1152/ajpendo.00019.2003

M3 - Article

VL - 285

SP - E1273 - E1281

JO - AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM

JF - AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM

IS - 6

ER -

Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this