Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

D. S. Mansell; V. D. Bruno; E. Sammut; A. Chiribiri; T. Johnson; I. Khaliulin; D. Baz Lopez; H. S. Gill; K. H. Fraser; M. Murphy; T. Krieg; M. S. Suleiman; S. George; R. Ascione; A. N. Cookson

doi:10.1038/s41598-021-97834-y

Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

D. S. Mansell, V. D. Bruno, E. Sammut, A. Chiribiri, T. Johnson, I. Khaliulin, D. Baz Lopez, H. S. Gill, K. H. Fraser, M. Murphy, T. Krieg, M. S. Suleiman, S. George, R. Ascione^*, A. N. Cookson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5-6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5-6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.

Original language	English
Article number	18322
Pages (from-to)	18322
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-97834-y
Publication status	Published - 15 Sept 2021

Keywords

Animals
Biomarkers
Computational Biology/methods
Data Analysis
Data Interpretation, Statistical
Disease Models, Animal
Disease Susceptibility
Female
Image Processing, Computer-Assisted
Magnetic Resonance Imaging/methods
Myocardial Infarction/diagnostic imaging
Myocardium/metabolism
Proteome
Proteomics/methods
Reproducibility of Results
Swine
Translational Research, Biomedical
Ventricular Function, Left
Ventricular Remodeling

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10.1038/s41598-021-97834-y

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Mansell, D. S., Bruno, V. D., Sammut, E., Chiribiri, A., Johnson, T., Khaliulin, I., Lopez, D. B., Gill, H. S., Fraser, K. H., Murphy, M., Krieg, T., Suleiman, M. S., George, S., Ascione, R., & Cookson, A. N. (2021). Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model. Scientific Reports, 11(1), 18322. Article 18322. https://doi.org/10.1038/s41598-021-97834-y

@article{ca6146e559084da5b132efc8214ef2e9,

title = "Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model",

abstract = "To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5-6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5-6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.",

keywords = "Animals, Biomarkers, Computational Biology/methods, Data Analysis, Data Interpretation, Statistical, Disease Models, Animal, Disease Susceptibility, Female, Image Processing, Computer-Assisted, Magnetic Resonance Imaging/methods, Myocardial Infarction/diagnostic imaging, Myocardium/metabolism, Proteome, Proteomics/methods, Reproducibility of Results, Swine, Translational Research, Biomedical, Ventricular Function, Left, Ventricular Remodeling",

author = "Mansell, {D. S.} and Bruno, {V. D.} and E. Sammut and A. Chiribiri and T. Johnson and I. Khaliulin and Lopez, {D. Baz} and Gill, {H. S.} and Fraser, {K. H.} and M. Murphy and T. Krieg and Suleiman, {M. S.} and S. George and R. Ascione and Cookson, {A. N.}",

note = "Funding Information: This work was supported by a Great West 4 (GW4) Initiator grant to Ascione (GW4-AF4-011) and partially by the University of Bath. In addition, this work was supported by the following grants to Ascione: Medical Research Council (MRC): MR/L012723/1; British Heart Foundation (BHF): IG/14/2/30991, PG/10/40/28369, PG/07/046/22772, and PG/16/104/32652) to Ascione, and by a Developmental Pathway Funding Scheme (DPFS) grant to Murphy, Krieg and Ascione (MR/M015769/1). Mansell was supported by an EPSRC DTP. Funding Information: The authors would like to thank the staff at the University of Bristol Translational Biomedical Research Centre, a national research facility for large animal co-funded by the British Heart Foundation and the Medical Research Council. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = sep,

day = "15",

doi = "10.1038/s41598-021-97834-y",

language = "English",

volume = "11",

pages = "18322",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Mansell, DS, Bruno, VD, Sammut, E, Chiribiri, A, Johnson, T, Khaliulin, I, Lopez, DB, Gill, HS, Fraser, KH, Murphy, M, Krieg, T, Suleiman, MS, George, S, Ascione, R & Cookson, AN 2021, 'Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model', Scientific Reports, vol. 11, no. 1, 18322, pp. 18322. https://doi.org/10.1038/s41598-021-97834-y

TY - JOUR

T1 - Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

AU - Mansell, D. S.

AU - Bruno, V. D.

AU - Sammut, E.

AU - Chiribiri, A.

AU - Johnson, T.

AU - Khaliulin, I.

AU - Lopez, D. Baz

AU - Gill, H. S.

AU - Fraser, K. H.

AU - Murphy, M.

AU - Krieg, T.

AU - Suleiman, M. S.

AU - George, S.

AU - Ascione, R.

AU - Cookson, A. N.

N1 - Funding Information: This work was supported by a Great West 4 (GW4) Initiator grant to Ascione (GW4-AF4-011) and partially by the University of Bath. In addition, this work was supported by the following grants to Ascione: Medical Research Council (MRC): MR/L012723/1; British Heart Foundation (BHF): IG/14/2/30991, PG/10/40/28369, PG/07/046/22772, and PG/16/104/32652) to Ascione, and by a Developmental Pathway Funding Scheme (DPFS) grant to Murphy, Krieg and Ascione (MR/M015769/1). Mansell was supported by an EPSRC DTP. Funding Information: The authors would like to thank the staff at the University of Bristol Translational Biomedical Research Centre, a national research facility for large animal co-funded by the British Heart Foundation and the Medical Research Council. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9/15

Y1 - 2021/9/15

N2 - To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5-6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5-6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.

AB - To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5-6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5-6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.

KW - Animals

KW - Biomarkers

KW - Computational Biology/methods

KW - Data Analysis

KW - Data Interpretation, Statistical

KW - Disease Models, Animal

KW - Disease Susceptibility

KW - Female

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging/methods

KW - Myocardial Infarction/diagnostic imaging

KW - Myocardium/metabolism

KW - Proteome

KW - Proteomics/methods

KW - Reproducibility of Results

KW - Swine

KW - Translational Research, Biomedical

KW - Ventricular Function, Left

KW - Ventricular Remodeling

UR - http://www.scopus.com/inward/record.url?scp=85115271951&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-97834-y

DO - 10.1038/s41598-021-97834-y

M3 - Article

C2 - 34526592

AN - SCOPUS:85115271951

SN - 2045-2322

VL - 11

SP - 18322

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 18322

ER -

Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

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Keywords

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