Acute Retinal Necrosis: The Effects of Intravitreal Foscarnet and Virus Type on Outcome

Roger Wong; Carlos E. Pavesio; Alistair Laidlaw; Tom H. Williamson; Elizabeth M. Graham; Miles Stanford

doi:10.1016/j.ophtha.2009.08.003

Acute Retinal Necrosis: The Effects of Intravitreal Foscarnet and Virus Type on Outcome

Roger Wong^*, Carlos E. Pavesio, Alistair Laidlaw, Tom H. Williamson, Elizabeth M. Graham, Miles Stanford

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

Purpose: To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN).

Design: Retrospective comparative case series.

Participants: Eighty-one eyes of 74 patients.

Methods: A retrospective case note analysis was performed in 2 tertiary referral centers.

Main Outcome Measures: Presenting and final visual acuity, and progression to retinal detachment.

Results: Thirty-three eyes had HSV-ARN and 48 had VZV-ARN. The average age for HSV-ARN was 34 years and 51 for VZV-ARN (P <0.001). Visual acuity on presentation was similar (P = 0.48), but a larger proportion had better vision (>= 20/60) in the HSV-ARN group (52%) than the VZV-ARN group (35%). A greater proportion of eyes with poor vision (

Conclusions: The results support the difference of outcome in HSV-ARN and VZV-ARN. Therefore, viral identification serves as a key to predicting outcome in these patients. Intravitreal foscarnet seems to be a useful adjunct for the treatment of ARN in that it reduced rate of retinal detachment.

Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

Original language	English
Pages (from-to)	556-560
Number of pages	5
Journal	Ophthalmology
Volume	117
Issue number	3
DOIs	https://doi.org/10.1016/j.ophtha.2009.08.003
Publication status	Published - Mar 2010

Keywords

MANAGEMENT
RETINITIS
INJECTIONS
PHOTOCOAGULATION
VITRECTOMY
DIAGNOSIS
THERAPY

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10.1016/j.ophtha.2009.08.003

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title = "Acute Retinal Necrosis: The Effects of Intravitreal Foscarnet and Virus Type on Outcome",

abstract = "Purpose: To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN).Design: Retrospective comparative case series.Participants: Eighty-one eyes of 74 patients.Methods: A retrospective case note analysis was performed in 2 tertiary referral centers.Main Outcome Measures: Presenting and final visual acuity, and progression to retinal detachment.Results: Thirty-three eyes had HSV-ARN and 48 had VZV-ARN. The average age for HSV-ARN was 34 years and 51 for VZV-ARN (P <0.001). Visual acuity on presentation was similar (P = 0.48), but a larger proportion had better vision (>= 20/60) in the HSV-ARN group (52%) than the VZV-ARN group (35%). A greater proportion of eyes with poor vision (Conclusions: The results support the difference of outcome in HSV-ARN and VZV-ARN. Therefore, viral identification serves as a key to predicting outcome in these patients. Intravitreal foscarnet seems to be a useful adjunct for the treatment of ARN in that it reduced rate of retinal detachment.Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.",

keywords = "MANAGEMENT, RETINITIS, INJECTIONS, PHOTOCOAGULATION, VITRECTOMY, DIAGNOSIS, THERAPY",

author = "Roger Wong and Pavesio, {Carlos E.} and Alistair Laidlaw and Williamson, {Tom H.} and Graham, {Elizabeth M.} and Miles Stanford",

year = "2010",

month = mar,

doi = "10.1016/j.ophtha.2009.08.003",

language = "English",

volume = "117",

pages = "556--560",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

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T1 - Acute Retinal Necrosis

T2 - The Effects of Intravitreal Foscarnet and Virus Type on Outcome

AU - Wong, Roger

AU - Pavesio, Carlos E.

AU - Laidlaw, Alistair

AU - Williamson, Tom H.

AU - Graham, Elizabeth M.

AU - Stanford, Miles

PY - 2010/3

Y1 - 2010/3

N2 - Purpose: To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN).Design: Retrospective comparative case series.Participants: Eighty-one eyes of 74 patients.Methods: A retrospective case note analysis was performed in 2 tertiary referral centers.Main Outcome Measures: Presenting and final visual acuity, and progression to retinal detachment.Results: Thirty-three eyes had HSV-ARN and 48 had VZV-ARN. The average age for HSV-ARN was 34 years and 51 for VZV-ARN (P <0.001). Visual acuity on presentation was similar (P = 0.48), but a larger proportion had better vision (>= 20/60) in the HSV-ARN group (52%) than the VZV-ARN group (35%). A greater proportion of eyes with poor vision (Conclusions: The results support the difference of outcome in HSV-ARN and VZV-ARN. Therefore, viral identification serves as a key to predicting outcome in these patients. Intravitreal foscarnet seems to be a useful adjunct for the treatment of ARN in that it reduced rate of retinal detachment.Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

AB - Purpose: To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN).Design: Retrospective comparative case series.Participants: Eighty-one eyes of 74 patients.Methods: A retrospective case note analysis was performed in 2 tertiary referral centers.Main Outcome Measures: Presenting and final visual acuity, and progression to retinal detachment.Results: Thirty-three eyes had HSV-ARN and 48 had VZV-ARN. The average age for HSV-ARN was 34 years and 51 for VZV-ARN (P <0.001). Visual acuity on presentation was similar (P = 0.48), but a larger proportion had better vision (>= 20/60) in the HSV-ARN group (52%) than the VZV-ARN group (35%). A greater proportion of eyes with poor vision (Conclusions: The results support the difference of outcome in HSV-ARN and VZV-ARN. Therefore, viral identification serves as a key to predicting outcome in these patients. Intravitreal foscarnet seems to be a useful adjunct for the treatment of ARN in that it reduced rate of retinal detachment.Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.

KW - MANAGEMENT

KW - RETINITIS

KW - INJECTIONS

KW - PHOTOCOAGULATION

KW - VITRECTOMY

KW - DIAGNOSIS

KW - THERAPY

U2 - 10.1016/j.ophtha.2009.08.003

DO - 10.1016/j.ophtha.2009.08.003

M3 - Article

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VL - 117

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EP - 560

JO - Ophthalmology

JF - Ophthalmology

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ER -

Acute Retinal Necrosis: The Effects of Intravitreal Foscarnet and Virus Type on Outcome

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Keywords

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