Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome

Clodagh Murphy; Peter Deeley; E. M. Daly; C. Ecker; F. M. O&apos;Brien; B. Hallahan; E. Loth; F. Toal; Suzie Reed; S. Hales; D. M. Robertson; M. C. Craig; D. Mullins; G. J. Barker; T. Lavender; P. Johnston; K. C. Murphy; D. G. Murphy

doi:10.1002/aur.227

Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome

Clodagh Murphy, Peter Deeley, E. M. Daly, C. Ecker, F. M. O'Brien, B. Hallahan, E. Loth, F. Toal, Suzie Reed, S. Hales, D. M. Robertson, M. C. Craig, D. Mullins, G. J. Barker, T. Lavender, P. Johnston, K. C. Murphy, D. G. Murphy

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Abstract

It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (1247 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P

Original language	English
Pages (from-to)	3 - 12
Number of pages	10
Journal	Autism research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1002/aur.227
Publication status	Published - Feb 2012

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Murphy, C., Deeley, P., Daly, E. M., Ecker, C., O'Brien, F. M., Hallahan, B., Loth, E., Toal, F., Reed, S., Hales, S., Robertson, D. M., Craig, M. C., Mullins, D., Barker, G. J., Lavender, T., Johnston, P., Murphy, K. C., & Murphy, D. G. (2012). Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome. Autism research, 5(1), 3 - 12. https://doi.org/10.1002/aur.227

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title = "Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome",

abstract = "It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (1247 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P",

author = "Clodagh Murphy and Peter Deeley and Daly, {E. M.} and C. Ecker and O'Brien, {F. M.} and B. Hallahan and E. Loth and F. Toal and Suzie Reed and S. Hales and Robertson, {D. M.} and Craig, {M. C.} and D. Mullins and Barker, {G. J.} and T. Lavender and P. Johnston and Murphy, {K. C.} and Murphy, {D. G.}",

year = "2012",

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doi = "10.1002/aur.227",

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Murphy, C , Deeley, P , Daly, EM , Ecker, C, O'Brien, FM, Hallahan, B , Loth, E , Toal, F, Reed, S, Hales, S , Robertson, DM , Craig, MC , Mullins, D , Barker, GJ , Lavender, T, Johnston, P, Murphy, KC & Murphy, DG 2012, 'Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome', Autism research, vol. 5, no. 1, pp. 3 - 12. https://doi.org/10.1002/aur.227

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AU - Murphy, Clodagh

AU - Deeley, Peter

AU - Daly, E. M.

AU - Ecker, C.

AU - O'Brien, F. M.

AU - Hallahan, B.

AU - Loth, E.

AU - Toal, F.

AU - Reed, Suzie

AU - Hales, S.

AU - Robertson, D. M.

AU - Craig, M. C.

AU - Mullins, D.

AU - Barker, G. J.

AU - Lavender, T.

AU - Johnston, P.

AU - Murphy, K. C.

AU - Murphy, D. G.

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Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome

Abstract

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