@inbook{6330da873d09454ab0f9bd37b9ed56e8,
title = "Anisotropy in the Human Placenta in Pregnancies Complicated by Fetal Growth Restriction",
abstract = "The placenta has a unique structure, which enables the transfer of oxygen and nutrients from the mother to the developing fetus. Abnormalities in placental structure are associated with major complications of pregnancy; for instance, changes in the complex branching structures of fetal villous trees are associated with fetal growth restriction. Diffusion MRI has the potential to measure such fine placental microstructural details. Here, we present in-vivo placental diffusion MRI scans from controls and pregnancies complicated by fetal growth restriction. We find that after 30 weeks{\textquoteright} gestation fractional anisotropy is significantly higher in placentas associated with growth restricted pregnancies. This shows the potential of diffusion MRI derived measures of anisotropy for assessing placental function during pregnancy.",
keywords = "Anisotropy, Diffusion, Fetal growth restriction, Microstructure, MRI, Placenta, Pregnancy, Villous trees",
author = "Slator, {Paddy J.} and Alison Ho and Spyros Bakalis and Laurence Jackson and Chappell, {Lucy C.} and Alexander, {Daniel C.} and Hajnal, {Joseph V.} and Mary Rutherford and Jana Hutter",
note = "Funding Information: Acknowledgments We thank all mothers, midwives, obstetricians, and radiographers who played a key role in obtaining the datasets. This work was supported by the NIH Human Placenta Project grant 1U01HD087202-01 (Placenta Imaging Project [PiP]); Wellcome Trust (201374/Z/16/Z); EPSRC (N018702, M020533, EP/N018702/1); NIHR (RP-2014-05-019); the Wellcome EPSRC Centre for Medical Engineering at Kings College London (WT 203148/Z/16/Z) and by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and Kings{\textquoteright} College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.; Workshop on Visualization and Processing of Anisotropy in Imaging, Geometry, and Astronomy, 2018 ; Conference date: 28-10-2018 Through 02-11-2018",
year = "2021",
doi = "10.1007/978-3-030-56215-1_13",
language = "English",
isbn = "9783030562144",
series = "Mathematics and Visualization",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "263--276",
editor = "Evren {\"O}zarslan and Thomas Schultz and Eugene Zhang and Andrea Fuster",
booktitle = "Anisotropy Across Fields and Scales",
address = "Germany",
}