TY - JOUR
T1 - Anorexia nervosa
T2 - diagnostic, therapeutic, and risk biomarkers in clinical practice
AU - Himmerich, Hubertus
AU - Treasure, Janet
N1 - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2024/4
Y1 - 2024/4
N2 - In anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the diagnosis, diagnostic specification, risk management, choice of therapy, therapy monitoring, and treatment review. History-taking, physical and neuropsychological examination, clinical observation, and judgment about treatment success by the patient, their carers, and members of the multidisciplinary team are essential to interpret laboratory and imaging data appropriately and to assess the full clinical picture.
AB - In anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the diagnosis, diagnostic specification, risk management, choice of therapy, therapy monitoring, and treatment review. History-taking, physical and neuropsychological examination, clinical observation, and judgment about treatment success by the patient, their carers, and members of the multidisciplinary team are essential to interpret laboratory and imaging data appropriately and to assess the full clinical picture.
KW - Humans
KW - Anorexia Nervosa/diagnosis
KW - Treatment Outcome
UR - http://www.scopus.com/inward/record.url?scp=85184574529&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2024.01.002
DO - 10.1016/j.molmed.2024.01.002
M3 - Review article
C2 - 38331700
SN - 1471-4914
VL - 30
SP - 350
EP - 360
JO - TRENDS IN MOLECULAR MEDICINE
JF - TRENDS IN MOLECULAR MEDICINE
IS - 4
ER -