Are abnormal premorbid personality traits associated with Alzheimer's disease? A case-control study

Helen Nicholas; Paul Moran; Catherine Foy; Richard G. Brown; Simon Lovestone; Stephanie Bryant; Harry Boothby

doi:10.1002/gps.2345

Are abnormal premorbid personality traits associated with Alzheimer's disease? A case-control study

Helen Nicholas, Paul Moran, Catherine Foy, Richard G. Brown, Simon Lovestone, Stephanie Bryant, Harry Boothby

Farnham Rd Hosp, Dept Old Age Psychiat

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Objective: To examine the association between premorbid personality traits, social networks and AD, using a case-control design, and two informant-based retrospective assessments of premorbid personality.Methods: Cases consisted of 217 Subjects diagnosed with probable late onset Alzheimer's disease (160 females and 57 males). Recruitment was from both community and nursing home settings. Controls consisted of 76 unaffected siblings (44 females and 32 males) of patients with AD. Both cases and controls received informant ratings of premorbid personality.Results: A selection of abnormal personality traits were over represented in the AD group. AD was particularly associated with Cluster A personality disorder traits (Paranoid, Schizoid, Schizotypal). AD cases had correspondingly sparser social networks.Conclusions: There is an association between abnormal personality traits and AD. Individuals with AD also appear to have had lower levels of social interactivity.

Original language	English
Article number	N/A
Pages (from-to)	345 - 351
Number of pages	7
Journal	International Journal of Geriatric Psychiatry
Volume	25
Issue number	4
DOIs	https://doi.org/10.1002/gps.2345
Publication status	Published - Apr 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/gps.2345

Cite this

@article{d31266bc2ee146af81543a589b6e2985,

title = "Are abnormal premorbid personality traits associated with Alzheimer's disease? A case-control study",

abstract = "Objective: To examine the association between premorbid personality traits, social networks and AD, using a case-control design, and two informant-based retrospective assessments of premorbid personality.Methods: Cases consisted of 217 Subjects diagnosed with probable late onset Alzheimer's disease (160 females and 57 males). Recruitment was from both community and nursing home settings. Controls consisted of 76 unaffected siblings (44 females and 32 males) of patients with AD. Both cases and controls received informant ratings of premorbid personality.Results: A selection of abnormal personality traits were over represented in the AD group. AD was particularly associated with Cluster A personality disorder traits (Paranoid, Schizoid, Schizotypal). AD cases had correspondingly sparser social networks.Conclusions: There is an association between abnormal personality traits and AD. Individuals with AD also appear to have had lower levels of social interactivity. ",

author = "Helen Nicholas and Paul Moran and Catherine Foy and Brown, {Richard G.} and Simon Lovestone and Stephanie Bryant and Harry Boothby",

year = "2010",

month = apr,

doi = "10.1002/gps.2345",

language = "English",

volume = "25",

pages = "345 -- 351",

journal = "International Journal of Geriatric Psychiatry",

issn = "1099-1166",

publisher = "WILEY-BLACKWELL",

number = "4",

}

TY - JOUR

T1 - Are abnormal premorbid personality traits associated with Alzheimer's disease? A case-control study

AU - Nicholas, Helen

AU - Moran, Paul

AU - Foy, Catherine

AU - Brown, Richard G.

AU - Lovestone, Simon

AU - Bryant, Stephanie

AU - Boothby, Harry

PY - 2010/4

Y1 - 2010/4

N2 - Objective: To examine the association between premorbid personality traits, social networks and AD, using a case-control design, and two informant-based retrospective assessments of premorbid personality.Methods: Cases consisted of 217 Subjects diagnosed with probable late onset Alzheimer's disease (160 females and 57 males). Recruitment was from both community and nursing home settings. Controls consisted of 76 unaffected siblings (44 females and 32 males) of patients with AD. Both cases and controls received informant ratings of premorbid personality.Results: A selection of abnormal personality traits were over represented in the AD group. AD was particularly associated with Cluster A personality disorder traits (Paranoid, Schizoid, Schizotypal). AD cases had correspondingly sparser social networks.Conclusions: There is an association between abnormal personality traits and AD. Individuals with AD also appear to have had lower levels of social interactivity.

AB - Objective: To examine the association between premorbid personality traits, social networks and AD, using a case-control design, and two informant-based retrospective assessments of premorbid personality.Methods: Cases consisted of 217 Subjects diagnosed with probable late onset Alzheimer's disease (160 females and 57 males). Recruitment was from both community and nursing home settings. Controls consisted of 76 unaffected siblings (44 females and 32 males) of patients with AD. Both cases and controls received informant ratings of premorbid personality.Results: A selection of abnormal personality traits were over represented in the AD group. AD was particularly associated with Cluster A personality disorder traits (Paranoid, Schizoid, Schizotypal). AD cases had correspondingly sparser social networks.Conclusions: There is an association between abnormal personality traits and AD. Individuals with AD also appear to have had lower levels of social interactivity.

U2 - 10.1002/gps.2345

DO - 10.1002/gps.2345

M3 - Article

SN - 1099-1166

VL - 25

SP - 345

EP - 351

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

IS - 4

M1 - N/A

ER -

Are abnormal premorbid personality traits associated with Alzheimer's disease? A case-control study

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this