Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: Incorporation of α1-antitrypsin into the coatings

Zheng Liang Zhi; Jashandeep Singh; Amazon L F Austin; David C D Hope; Aileen J. King; Shanta J. Persaud; Peter M. Jones

doi:10.1039/c5cc02570b

Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: Incorporation of α1-antitrypsin into the coatings

Zheng Liang Zhi^*, Jashandeep Singh, Amazon L F Austin, David C D Hope, Aileen J. King, Shanta J. Persaud, Peter M. Jones

^*Corresponding author for this work

Diabetes

Diabetes UK

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating α1-antitrypsin, an anti-inflammatory protein, exhibited effective anti-coagulant activities in vitro.

Original language	English
Pages (from-to)	10652-10655
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	51
Issue number	53
DOIs	https://doi.org/10.1039/c5cc02570b
Publication status	Published - 7 Jul 2015

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abstract = "A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating α1-antitrypsin, an anti-inflammatory protein, exhibited effective anti-coagulant activities in vitro.",

author = "Zhi, {Zheng Liang} and Jashandeep Singh and Austin, {Amazon L F} and Hope, {David C D} and King, {Aileen J.} and Persaud, {Shanta J.} and Jones, {Peter M.}",

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T2 - Incorporation of α1-antitrypsin into the coatings

AU - Zhi, Zheng Liang

AU - Singh, Jashandeep

AU - Austin, Amazon L F

AU - Hope, David C D

AU - King, Aileen J.

AU - Persaud, Shanta J.

AU - Jones, Peter M.

PY - 2015/7/7

Y1 - 2015/7/7

N2 - A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating α1-antitrypsin, an anti-inflammatory protein, exhibited effective anti-coagulant activities in vitro.

AB - A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating α1-antitrypsin, an anti-inflammatory protein, exhibited effective anti-coagulant activities in vitro.

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DO - 10.1039/c5cc02570b

M3 - Article

AN - SCOPUS:84934887725

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JO - Chemical communications (Cambridge, England)

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ER -

Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: Incorporation of α1-antitrypsin into the coatings

Abstract

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