TY - JOUR
T1 - Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern
T2 - A European-DLB consortium project
AU - Bauckneht, Matteo
AU - Chincarini, Andrea
AU - Brendel, Matthias
AU - Rominger, Axel
AU - Beyer, Leonie
AU - Bruffaerts, Rose
AU - Vandenberghe, Rik
AU - Kramberger, Milica G.
AU - Trost, Maja
AU - Garibotto, Valentina
AU - Nicastro, Nicolas
AU - Frisoni, Giovanni B.
AU - Lemstra, Afina W.
AU - van Berckel, Bart N.M.
AU - Pilotto, Andrea
AU - Padovani, Alessandro
AU - Ochoa-Figueroa, Miguel A.
AU - Davidsson, Anette
AU - Camacho, Valle
AU - Peira, Enrico
AU - Arnaldi, Dario
AU - Pardini, Matteo
AU - Donegani, Maria Isabella
AU - Raffa, Stefano
AU - Miceli, Alberto
AU - Sambuceti, Gianmario
AU - Aarsland, Dag
AU - Nobili, Flavio
AU - Morbelli, Silvia
N1 - Funding Information:
informationM.B. and S.M. were supported by grants from the Italian Ministry of Health - 5 ? 1000 funds 2016; R.B. is a senior postdoctoral fellow of the Research Foundation Flanders (FWO); V.G. was supported by the Swiss National Science Foundation (projects 320030_185028 and 320030_169876). This paper represents independent research partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King?s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Funding Information:
S.M. and F.N. have received speaker honoraria from GE Healthcare and Eli‐Lilly; V.G. received research/teaching funding from Siemens Healthineers, GE Healthcare, Roche, Merck, and Life Molecular Imaging. M.B. received speaker honoraria from GE Healthcare and LMI and is an advisor of LMI.
Publisher Copyright:
© 2021 the Alzheimer's Association
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non–disease-related variables such as age and cognitive reserve.
AB - Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non–disease-related variables such as age and cognitive reserve.
KW - biomarkers
KW - cognitive reserve
KW - dementia with Lewy bodies
KW - fluorodeoxyglucose positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85100215894&partnerID=8YFLogxK
U2 - 10.1002/alz.12294
DO - 10.1002/alz.12294
M3 - Article
AN - SCOPUS:85100215894
SN - 1552-5260
VL - 17
SP - 1277
EP - 1286
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 8
ER -
