Autism risk associated with parental age and with increasing difference in age between the parents

S. Sandin; D. Schendel; P. Magnusson; C. Hultman; P. Surén; E. Susser; T. GrØnborg; M. Gissler; N. Gunnes; R. Gross; M. Henning; M. Bresnahan; A. Sourander; M. Hornig; K. Carter; R. Francis; E. Parner; H. Leonard; M. Rosanoff; C. Stoltenberg; A. Reichenberg

doi:10.1038/mp.2015.70

Autism risk associated with parental age and with increasing difference in age between the parents

S. Sandin^*, D. Schendel, P. Magnusson, C. Hultman, P. Surén, E. Susser, T. GrØnborg, M. Gissler, N. Gunnes, R. Gross, M. Henning, M. Bresnahan, A. Sourander, M. Hornig, K. Carter, R. Francis, E. Parner, H. Leonard, M. Rosanoff, C. StoltenbergA. Reichenberg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

176 Citations (Scopus)

Abstract

Advancing paternal and maternal age have both been associated with risk for autism spectrum disorders (ASD). However, the shape of the association remains unclear, and results on the joint associations is lacking. This study tests if advancing paternal and maternal ages are independently associated with ASD risk and estimates the functional form of the associations. In a population-based cohort study from five countries (Denmark, Israel, Norway, Sweden and Western Australia) comprising 5 766 794 children born 1985-2004 and followed up to the end of 2004-2009, the relative risk (RR) of ASD was estimated by using logistic regression and splines. Our analyses included 30 902 cases of ASD. Advancing paternal and maternal age were each associated with increased RR of ASD after adjusting for confounding and the other parent's age (mothers 40-49 years vs 20-29 years, RR=1.15 (95% confidence interval (CI): 1.06-1.24), P-value

Original language	English
Pages (from-to)	693-700
Number of pages	8
Journal	Molecular Psychiatry
Volume	21
Issue number	5
Early online date	9 Jun 2015
DOIs	https://doi.org/10.1038/mp.2015.70
Publication status	Published - 1 May 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/mp.2015.70

Cite this

Sandin, S., Schendel, D., Magnusson, P., Hultman, C., Surén, P., Susser, E., GrØnborg, T., Gissler, M., Gunnes, N., Gross, R., Henning, M., Bresnahan, M., Sourander, A., Hornig, M., Carter, K., Francis, R., Parner, E., Leonard, H., Rosanoff, M., ... Reichenberg, A. (2016). Autism risk associated with parental age and with increasing difference in age between the parents. Molecular Psychiatry, 21(5), 693-700. https://doi.org/10.1038/mp.2015.70

@article{c0124eaf3c7b4652b06417f1868c101a,

title = "Autism risk associated with parental age and with increasing difference in age between the parents",

abstract = "Advancing paternal and maternal age have both been associated with risk for autism spectrum disorders (ASD). However, the shape of the association remains unclear, and results on the joint associations is lacking. This study tests if advancing paternal and maternal ages are independently associated with ASD risk and estimates the functional form of the associations. In a population-based cohort study from five countries (Denmark, Israel, Norway, Sweden and Western Australia) comprising 5 766 794 children born 1985-2004 and followed up to the end of 2004-2009, the relative risk (RR) of ASD was estimated by using logistic regression and splines. Our analyses included 30 902 cases of ASD. Advancing paternal and maternal age were each associated with increased RR of ASD after adjusting for confounding and the other parent's age (mothers 40-49 years vs 20-29 years, RR=1.15 (95% confidence interval (CI): 1.06-1.24), P-value",

author = "S. Sandin and D. Schendel and P. Magnusson and C. Hultman and P. Sur{\'e}n and E. Susser and T. Gr{\O}nborg and M. Gissler and N. Gunnes and R. Gross and M. Henning and M. Bresnahan and A. Sourander and M. Hornig and K. Carter and R. Francis and E. Parner and H. Leonard and M. Rosanoff and C. Stoltenberg and A. Reichenberg",

year = "2016",

month = may,

day = "1",

doi = "10.1038/mp.2015.70",

language = "English",

volume = "21",

pages = "693--700",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Springer Nature [academic journals on nature.com]",

number = "5",

}

Sandin, S, Schendel, D, Magnusson, P, Hultman, C, Surén, P, Susser, E, GrØnborg, T, Gissler, M, Gunnes, N, Gross, R, Henning, M, Bresnahan, M, Sourander, A, Hornig, M, Carter, K, Francis, R, Parner, E, Leonard, H, Rosanoff, M, Stoltenberg, C & Reichenberg, A 2016, 'Autism risk associated with parental age and with increasing difference in age between the parents', Molecular Psychiatry, vol. 21, no. 5, pp. 693-700. https://doi.org/10.1038/mp.2015.70

TY - JOUR

T1 - Autism risk associated with parental age and with increasing difference in age between the parents

AU - Sandin, S.

AU - Schendel, D.

AU - Magnusson, P.

AU - Hultman, C.

AU - Surén, P.

AU - Susser, E.

AU - GrØnborg, T.

AU - Gissler, M.

AU - Gunnes, N.

AU - Gross, R.

AU - Henning, M.

AU - Bresnahan, M.

AU - Sourander, A.

AU - Hornig, M.

AU - Carter, K.

AU - Francis, R.

AU - Parner, E.

AU - Leonard, H.

AU - Rosanoff, M.

AU - Stoltenberg, C.

AU - Reichenberg, A.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Advancing paternal and maternal age have both been associated with risk for autism spectrum disorders (ASD). However, the shape of the association remains unclear, and results on the joint associations is lacking. This study tests if advancing paternal and maternal ages are independently associated with ASD risk and estimates the functional form of the associations. In a population-based cohort study from five countries (Denmark, Israel, Norway, Sweden and Western Australia) comprising 5 766 794 children born 1985-2004 and followed up to the end of 2004-2009, the relative risk (RR) of ASD was estimated by using logistic regression and splines. Our analyses included 30 902 cases of ASD. Advancing paternal and maternal age were each associated with increased RR of ASD after adjusting for confounding and the other parent's age (mothers 40-49 years vs 20-29 years, RR=1.15 (95% confidence interval (CI): 1.06-1.24), P-value

AB - Advancing paternal and maternal age have both been associated with risk for autism spectrum disorders (ASD). However, the shape of the association remains unclear, and results on the joint associations is lacking. This study tests if advancing paternal and maternal ages are independently associated with ASD risk and estimates the functional form of the associations. In a population-based cohort study from five countries (Denmark, Israel, Norway, Sweden and Western Australia) comprising 5 766 794 children born 1985-2004 and followed up to the end of 2004-2009, the relative risk (RR) of ASD was estimated by using logistic regression and splines. Our analyses included 30 902 cases of ASD. Advancing paternal and maternal age were each associated with increased RR of ASD after adjusting for confounding and the other parent's age (mothers 40-49 years vs 20-29 years, RR=1.15 (95% confidence interval (CI): 1.06-1.24), P-value

UR - http://www.scopus.com/inward/record.url?scp=84930787620&partnerID=8YFLogxK

U2 - 10.1038/mp.2015.70

DO - 10.1038/mp.2015.70

M3 - Article

AN - SCOPUS:84930787620

SN - 1359-4184

VL - 21

SP - 693

EP - 700

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 5

ER -

Autism risk associated with parental age and with increasing difference in age between the parents

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this