Abstract
Intrahepatic cholestasis of pregnancy (ICP) is a common disease affecting up to 5% of pregnancies and which can cause fetal arrhythmia and sudden intrauterine death. We previously demonstrated that bile acid taurocholate (TC), which is raised in the bloodstream of ICP, can acutely alter the rate and rhythm of contraction and induce abnormal calcium destabilization in cultured neonatal rat cardiomyocytes (NRCM). Apart from their hepatic functions bile acids are ubiquitous signalling molecules with diverse systemic effects mediated by either the nuclear receptor FXR or by a recently discovered G-protein coupled receptor TGR5. We aim to investigate the mechanism of bile-acid induced arrhythmogenic effects in an in-vitro model of the fetal heart.
Original language | English |
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Pages (from-to) | e9689 |
Journal | PLoS ONE |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2010 |
Keywords
- Animals
- Cholestasis
- Gene Silencing
- Receptor, Muscarinic M2
- Cell Nucleus
- Receptors, G-Protein-Coupled
- Rats
- Animals, Newborn
- Polymerase Chain Reaction
- Bile Acids and Salts
- Rats, Wistar
- Myocytes, Cardiac
- Signal Transduction
- Arrhythmias, Cardiac