Patel, N., Masaratana, P., Diaz-Castro, J., Latunde-Dada, G. O., Qureshi, A., Lockyer, P., Jacob, M., Arno, M., Matak, P., Mitry, R. R., Hughes, R. D., Dhawan, A., Patterson, C., Simpson, R. J., & McKie, A. T. (2012). BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice. Journal of Biological Chemistry, 287(6), 4099 - 4106. https://doi.org/10.1074/jbc.M111.310789
Patel, Neeta ; Masaratana, Patarabutr ; Diaz-Castro, Javier et al. / BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 6. pp. 4099 - 4106.
@article{f033e74197cf43b5912ec3c96f54f00e,
title = "BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice",
abstract = "The BMP/SMAD4 pathway has major effects on liver hepcidin levels. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (Bmper), a known regulator of BMP signaling, was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trfhpx/hpx). Soluble BMPER peptide inhibited BMP2- and BMP6-dependent hepcidin promoter activity in both HepG2 and HuH7 cells. These effects correlated with reduced cellular levels of pSMAD1/5/8. Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, whereas injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels. Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.",
author = "Neeta Patel and Patarabutr Masaratana and Javier Diaz-Castro and Latunde-Dada, {Gladys O.} and Aakafa Qureshi and Pamela Lockyer and Molly Jacob and Matthew Arno and Pavle Matak and Mitry, {Ragai R.} and Hughes, {Robin D.} and Anil Dhawan and Cam Patterson and Simpson, {Robert J.} and McKie, {Andrew T.}",
year = "2012",
month = feb,
day = "3",
doi = "10.1074/jbc.M111.310789",
language = "English",
volume = "287",
pages = "4099 -- 4106",
journal = "Journal of Biological Chemistry",
issn = "1083-351X",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "6",
}
Patel, N, Masaratana, P, Diaz-Castro, J, Latunde-Dada, GO, Qureshi, A, Lockyer, P, Jacob, M, Arno, M, Matak, P, Mitry, RR, Hughes, RD, Dhawan, A, Patterson, C, Simpson, RJ & McKie, AT 2012, 'BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice', Journal of Biological Chemistry, vol. 287, no. 6, pp. 4099 - 4106. https://doi.org/10.1074/jbc.M111.310789
BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice. / Patel, Neeta; Masaratana, Patarabutr; Diaz-Castro, Javier et al.
In:
Journal of Biological Chemistry, Vol. 287, No. 6, 03.02.2012, p. 4099 - 4106.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice
AU - Patel, Neeta
AU - Masaratana, Patarabutr
AU - Diaz-Castro, Javier
AU - Latunde-Dada, Gladys O.
AU - Qureshi, Aakafa
AU - Lockyer, Pamela
AU - Jacob, Molly
AU - Arno, Matthew
AU - Matak, Pavle
AU - Mitry, Ragai R.
AU - Hughes, Robin D.
AU - Dhawan, Anil
AU - Patterson, Cam
AU - Simpson, Robert J.
AU - McKie, Andrew T.
PY - 2012/2/3
Y1 - 2012/2/3
N2 - The BMP/SMAD4 pathway has major effects on liver hepcidin levels. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (Bmper), a known regulator of BMP signaling, was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trfhpx/hpx). Soluble BMPER peptide inhibited BMP2- and BMP6-dependent hepcidin promoter activity in both HepG2 and HuH7 cells. These effects correlated with reduced cellular levels of pSMAD1/5/8. Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, whereas injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels. Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.
AB - The BMP/SMAD4 pathway has major effects on liver hepcidin levels. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (Bmper), a known regulator of BMP signaling, was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trfhpx/hpx). Soluble BMPER peptide inhibited BMP2- and BMP6-dependent hepcidin promoter activity in both HepG2 and HuH7 cells. These effects correlated with reduced cellular levels of pSMAD1/5/8. Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, whereas injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels. Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.
U2 - 10.1074/jbc.M111.310789
DO - 10.1074/jbc.M111.310789
M3 - Article
SN - 1083-351X
VL - 287
SP - 4099
EP - 4106
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 6
ER -
Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada GO, Qureshi A, Lockyer P et al. BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice. Journal of Biological Chemistry. 2012 Feb 3;287(6):4099 - 4106. doi: 10.1074/jbc.M111.310789